Effect of NO Precursors on Physiological Responses to Exercise

Physiology Clinical Trial

— NO-SUP  

Official title:

The Effect of NO Precursors on Physiological Responses to Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02850367
• Other study ID #: 38RC14.430
• Status: Completed
• Phase: N/A
• Start date: May 9, 2016
• Est. completion date: September 2021

Study information

• Verified date: January 2020
• Source: University Hospital, Grenoble
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 63
• Est. completion date: September 2021
• Est. primary completion date: September 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Sedentary subjects

• No cardiovascular, respiratory, metabolic and neurological disorders

Exclusion Criteria:

• Body mass index > 28 kg.m-2

• Smoker

• Alcool intake > 10g/day

• Psychiatric diseases

• Subjects under treatment able to interfere with their cardiovascular, metabolic and neurological status

Related Conditions & MeSH terms

• Physiology

Intervention

Dietary Supplement:
• Nitrate
Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.
• Nitrate and L-Arginine
Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.
• Nitrate and L-Citrulline
Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.
• Placebo
Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with a placebo.

Biological:
• Evaluation of post-ischemic vascular reactivity
After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.
• Neuromuscular evaluations
After the intake of the supplement. Measure the stretching force in the ankle (N)

Locations

Country	Name	City	State
France	Grenoble University Hospital	Grenoble	Rhone Alpes

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Grenoble

Country where clinical trial is conducted

France, 

References & Publications (60)

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* Note: There are 60 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neuromuscular evaluations	After the intake of the supplement. Measure the stretching force in the ankle (N)	3 half days
Primary	Evaluation of post-ischemic vascular reactivity	After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.	3 half days