Effects of Physical Exercise Timing On Strength and Cardiometabolic Health

Physical Inactivity Clinical Trial

— EPOCH  

Official title:

Effects of Physical Exercise Timing On Strength and Cardiometabolic Health

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06063135
• Other study ID #: EPOCH
• Status: Recruiting
• Phase: N/A
• Start date: November 21, 2023
• Est. completion date: May 31, 2026

Study information

• Verified date: February 2024
• Source: University of Basel
• Contact: Raphael Knaier, PhD
• Phone: +41612076877
• Email: epoch[@]unibas.ch
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Physical exercise is well known to improve human health. Current guidelines provide recommendations on the frequency, intensity, type and duration of exercise. However, they do not provide recommendations for the time of day, exercise should be performed. This is surprising considering that the influence of timing of behaviors such as sleep or nutrition as well as the impact of the circadian timing system on health are well documented. Further, there is evidence for diurnal variation in maximum performance which enables individuals to exercise with different intensities at different times of day, which in the long term might affect physical adaptations to exercise. Thus, this research study investigates if exercise timing impacts human health.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 105
• Est. completion date: May 31, 2026
• Est. primary completion date: May 31, 2026
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 80 Years

Eligibility

Inclusion Criteria:

• BMI 18.5 - 30 kg/m2

Exclusion Criteria:

• Structured resistance training within the last six months

• Ongoing shift work

• Irregular bedtime (> 2 hours variation in habitual bed time)

• Smoking

• Travels across more than two time zones within the last four weeks

• Inability to follow the study procedures (e.g. due to language barriers, psychological disorders, dementia, etc.)

• Known pregnancy or lactating women

• Participation in any other clinical trial within the last four weeks

• Medical condition that is a contra indicator for resistance training, endurance training, or exercising until maximum exhaustion including insufficiently controlled blood pressure (systolic > 170 mmHg, diastolic > 100 mmHg), ongoing cancer treatment, unstable angina pectoris, uncontrolled bradyarrhythmia or tachyarrhythmia, severe uncorrected valvular heart disease, clinically relevant acute infection, any form of musculoskeletal injury, orthopedic problems or decompensated cardiovascular disease

• Insulin dependent diabetes

• Participants using metformin

Related Conditions & MeSH terms

• Physical Inactivity

Intervention

Other:
• Physical Exercise Intervention
Two strength training session per week and one endurance training session per week

Locations

Country	Name	City	State
Switzerland	University of Basel	Basel

Sponsors (1)

Lead Sponsor	Collaborator
University of Basel

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximum strength	Mean value of the maximum isometric strength assessed at four different times of the day with an isometric mid-thigh pull on a force plate.	Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention)
Secondary	Glucose control	2-h postprandial area under the curve for glucose after an oral glucose tolerance test	Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention)
Secondary	Body composition	total body fat mass assessed with DXA	Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention)
Secondary	Cardiorespiratory fitness	VO2max assessed with cardiopulmonary exercise test	Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention)