Beta-alanine and Elder Endurance

Physical Endurance Clinical Trial

Official title:

The Interactive Effects Of Beta-Alanine Supplementation and Resistance Training on Muscular Endurance in Older Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02821481
• Other study ID #: 20140412
• Status: Completed
• Phase: N/A
• First received: June 28, 2016
• Last updated: August 31, 2017
• Start date: June 2016
• Est. completion date: June 2016

Study information

• Verified date: August 2017
• Source: University of Miami
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose for this study is to determine if beta-alanine supplementation combined with endurance-based resistance training can increase gains in muscular endurance to a greater extent than endurance-based resistance-training alone in older adults.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 27
• Est. completion date: June 2016
• Est. primary completion date: June 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 90 Years

Eligibility

Inclusion Criteria:

• 60-90 years of age

• Living independently (not residing in an assisted living facility)

• Through testing are found not to have sarcopenia

• Gait speed > 1 m/s

• Skeletal Muscle Index > 37% in men and > 27.6 % in women

• Exclusion Criteria

• Responding with a "yes" to any question on the PAR-Q.

• Are currently pregnant, or plan to try and become pregnant during the study

• Functional impairments that could impede the person's ability to participate in a resistance training program

• Current or recent use of supplements (within the past 3 months for non-alanine containing supplements or one year for supplements containing beta-alanine). Individuals taking only basic multivitamins (without any herbal co-ingredients) may still be allowed to participate. These situations will be reviewed on a case-by-case basis.

• Are currently enrolled in a regular exercise program (more than once per week)

• Current or recent smoker

• Use of medication containing corticosteroids

• Mini-mental score of 21 or below

• Severe musculoskeletal impairment

• Uncontrolled chronic disease

• Major depression

• Severe vestibular problems

Exclusion Criteria:

• Adults unable to consent

• Individuals who are not yet adults (infants, children, teenagers)

• Pregnant women

• Prisoners

Related Conditions & MeSH terms

• Physical Endurance

Intervention

Dietary Supplement:
• Beta-alanine

• Placebo

Behavioral:
• Muscular endurance exercise

Locations

Country	Name	City	State
United States	Max Orovitz Laboratories	Coral Gables	Florida

Sponsors (1)

Lead Sponsor	Collaborator
University of Miami

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Performance of Daily Activities	Short Physical Functional Performance test	baseline, 12 weeks
Secondary	Change in Body Fat	Body fat assessment via bioimpedance	baseline, 12 weeks
Secondary	Change in Muscular Endurance	20 repetitions to measure decline in muscular power across repetitions	baseline, 12 weeks
Secondary	Change in Muscular Strength	Maximal weight that could be lifted one time (1RM)	baseline, 12 weeks