The Association Between Sedentary Behaviour and Cardiometabolic Health in Trained Athletes

Physical Activity Clinical Trial

— HPAC  

Official title:

Do Trained Athletes Also Suffer From the Sedentary Behaviour Paradigm?: the Association Between Sedentary Behaviour and Cardiometabolic Health

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04711928
• Other study ID #: CME2020/012
• Status: Completed
• Start date: January 10, 2021
• Est. completion date: October 1, 2021

Study information

• Verified date: March 2022
• Source: Hasselt University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Physical inactivity is one of the major contributing factors for the development of chronic diseases and highly correlated with increased all-cause mortality. In the last decade an exponential growth in research concerned with the study of sedentary behaviour and the potential for detrimental effects on health have been published. In this field increasing evidence suggests that prolonged periods of sedentary time, independent of the amount of physical activity, also increases the risk for the development of several chronic conditions and all-cause mortality. Here, sedentary behaviour is defined as "any waking behaviour, characterized by a low energy expenditure (≤1.5 METs), while being in a sitting or reclining posture". Interestingly, the advised moderate-to-vigorous bouts of exercise recommended by the various guidelines cannot compensate the negative impact on health risks arising from prolonged periods of sitting. In other words, it seems that people compensate their total amount of physical activity after exercise training by decreasing their physical activity levels throughout the rest of the day. Here, it appears that frequent, even low-intensity interruptions of periods of sitting are required for good cardiometabolic health. Therefore, not only physical activity but also prolonged sitting should be targeted to optimize cardiometabolic health. Nevertheless, a recent harmonized meta-syntheses indicated that the association between self-reported sitting with all-cause and cardiovascular disease mortality are only partially independent of physical activity, but were particularly evident in those who undertake insufficient physical activity (<150min/week). However, it is unclear whether high amounts of objectively measured physical activity attenuates or even eliminates the detrimental effects of prolonged sitting. In addition, it is still unclear whether high amounts of physical activity can preserve a healthy cardiometabolic risk profile, despite prolonged sitting. Therefore, in this study we want to investigate the association between sedentary behaviour, physical activity and cardiometabolic health in highly physically active adults.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: October 1, 2021
• Est. primary completion date: August 1, 2021
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Active individuals with at least 4 training hours per week

Exclusion Criteria:

• pregnancy
• Any known contradiction for physical activity
• Systolic blood pressure >160mmHg, diastolic blood pressure >100mmHg
• More than 20 alcohol consumptions per week
• Participants diagnosed with any known chronic disease

Related Conditions & MeSH terms

• Athletes
• Cardiometabolic Health
• Physical Activity
• Sedentary Behavior

Intervention

Behavioral:
• Physical activity and sedentary behaviour
Athletes with a high physical activity and a low or high sedentary time

Locations

Country	Name	City	State
Belgium	Wouter Franssen	Diepenbeek	Limburg

Sponsors (1)

Lead Sponsor	Collaborator
Hasselt University

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Sedentary time (min/day)	Main outcome parameter of sedentary behaviour indication measured with ActivPAL3	day 1
Secondary	Moderate-to-vigorous physical activity time (min/day)	Physical activity parameter measured with ActivPAL3	day 1
Secondary	Light physical activity time (min/day)	Physical activity parameter measured with ActivPAL3	day 1
Secondary	Blood glucose concentration	Parameter of glucose homeostatis	day 1
Secondary	Blood insulin concentration	Parameter of glucose homeostatis	day1
Secondary	Blood total cholesterol concentration	Parameter of lipid metabolism	day 1
Secondary	Blood triglyceride concentration	Parameter of lipid metabolism	day 1
Secondary	Blood high density lipoprotein concentration	Parameter of lipid metabolism	day 1
Secondary	Blood low density lipoprotein concentration	Parameter of lipid metabolism	day 1
Secondary	Fat mass (kg)	Parameter of body composition measured with DEXA-scan	day 1
Secondary	Lean mass (kg)	Parameter of body composition measured with DEXA-scan	day 1
Secondary	Systolic blood pressure	Parameter of cardiovascular health	day 1
Secondary	Diastolic blood pressure	Parameter of cardiovascular health	day 1
Secondary	Maximal oxygen uptake	Parameter of oxygen capacity measured with cardiopulmonary exercise testing	day 1