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Neuropeptide Y and Sympathovagal Balance — NPY  

Physical Activity Clinical Trial

Official title:
Neuropeptide Y Function in the Sympathovagal Balance During an Ergometric Test in Healthy Volunteers

Clinical Trial Summary

Neuropeptide Y (NPY) activates the sympathetic and vagal nervous systems through the Y1 and Y2 receptors. This double-blind placebo-controlled crossover study investigated the sympathovagal balance during three exercises on a cycloergometer in healthy volunteers treated with saxagliptin (DPP4 inhibitor).

Clinical Trial Description

Pharmacological studies indicate that NPY has a role as a co-transmitter associated with catecholamines to maintain cardiovascular homeostasis. The development of a selective and sensitive assay of NPY1-36 (vasoconstrictor) and NPY3-36 (vasodilator) by LC-MS/MS will confirm this modulating role of NPY in sympatho vagal balance in healthy young subjects. This project should lead to a better understanding of the contribution of NPY to exercise physiology through a double-blind randomized study using a DPP4 inhibitor (Saxagliptin) used for the treatment of type 2 diabetes, blocking the formation of NPY3-36 and thus enhancing the effect of NPY1-36. The interest of this study will be to find targets other than adrenergic receptors in the regulation of sympathetic and parasympathetic systems during exercise. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03933787
Study type Interventional
Source Centre Hospitalier Universitaire Vaudois
Contact
Status Completed
Phase Early Phase 1
Start date June 5, 2018
Completion date April 15, 2019
View Details
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