Physical Activity Clinical Trial
Official title:
Brown Adipose Tissue Activation: Effect of Exercise Training and Irisin
This study investigates the brown adipose tissue (BAT) activation and metabolism using
positron emission tomography (PET) imaging before and after exercise training intervention at
fasting state under normal room temperature and during cold stimulation.The investigators
hypothesize that BAT glucose uptake is increased after exercise and BAT becomes metabolically
more active.
Understanding the mechanisms of BAT activation and the role of exercise in humans is crucial
to combat epidemic of obesity and diabetes.
Exercise training has been suggested to activate and recruit human BAT through the activation
of sympathetic nervous system and contracting skeletal muscles by the release of myokines
such as lactate and irisin that signal WAT to induce expression of beige adipocytes. It has
been also suggested that exercise training could enhance the metabolism of already existed
functional BAT by increasing uncoupling protein-1 (UCP-1) gene transcription, mitochondrial
biogenesis and hyperplasia. This is of clinical relevance because brown fat activation has
been found to improve metabolic factors linked to obesity and diabetes.
In this study the investigators use a PET radiotracer 2-[18F] flouro-2-deoxy-D-glucose (FDG)
to quantify the glucose uptake in BAT, whie adipose tissue and the muscle.The participants
are scanned thrice at fast in this study once at room temperature, second at cold exposure
and third after six weeks of exercise at cold exposure. This study will provide an insight
about the role of exercise in activation of BAT metabolism.
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