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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03275779
Other study ID # ERN_17-0997
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 1, 2018
Est. completion date December 1, 2018

Study information

Verified date December 2022
Source University of Birmingham
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study will investigate whether manipulating resistance exercise frequency impacts muscle protein synthesis rates. The investigators will test the hypothesise that a higher resistance exercise frequency will result in greater muscle protein synthesis rates than a lower resistance exercise frequency.


Description:

Resistance exercise is currently the most effective means of building or maintaining muscle mass. Resistance exercise guidelines generally suggest that those looking to increase muscle mass should train each muscle group once to twice per week. However, it has been proposed that it may be of greater benefit to train a muscle group with a higher frequency (i.e., four to six times per week) than currently suggested. If true, completing the same total volume of resistance exercise in more frequent, smaller bouts could prove to be a more beneficial strategy to optimally build or maintain muscle mass. Therefore, this study will investigate whether manipulating resistance exercise frequency impacts cumulative muscle protein synthesis rates in young individuals. Participants will undergo a 7 day period of habitual activity before completing the same total volume of resistance exercise as either; i) one isolated bout (low frequency) or ii) five smaller bouts (high frequency) over a period of 7 days.


Recruitment information / eligibility

Status Completed
Enrollment 9
Est. completion date December 1, 2018
Est. primary completion date December 1, 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 35 Years
Eligibility Inclusion Criteria: - Body mass index (18.5-29.99 kg/m2) - Untrained - defined as: Perform activities of daily living and recreation but have completed no regular lower body resistance-type exercise (e.g., weight training) activity in the last year. - Good general health Exclusion Criteria: - Lidocaine allergy - Hypertension (=140/90 mmHg) - Current participation in another clinical study - Previous participation in this study - Bleeding disorder/s - Current or recent smoker - Vegetarian or vegan - Past history of substance abuse and/or taking prescription or non-prescription medication (e.g., beta-blockers, insulin or thyroxine) or supplements that may influence normal metabolic responses.

Study Design


Related Conditions & MeSH terms


Intervention

Behavioral:
Low Frequency Condition
Young, untrained participants complete 7 days of habitual physical activity followed by a 7 day period where participants complete a single bout of unilateral resistance exercise.
High Frequency Condition
Young, untrained participants complete 7 days of habitual physical activity followed by a 7 day period where participants complete the same total volume of resistance exercise as the low frequency condition as five smaller bouts of unilateral resistance exercise.

Locations

Country Name City State
United Kingdom School of Sport Exercise and Rehabilitation Sciences, University of Birmingham Birmingham West Midlands

Sponsors (2)

Lead Sponsor Collaborator
University of Birmingham Maastricht University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Change in muscle protein synthesis (FSR %/day) The change in muscle protein synthesis rates (FSR %/day) from baseline will be determined between the low and high frequency conditions at days 10 and 15 using deuterium oxide (D2O). At day 10 and 15.
Secondary Change in satellite cell response The change in acute satellite cell response will be determined in muscle samples following low and high frequency resistance exercise at days 10 and 15. At day 10 and 15.
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