PBMT on Muscular Performance and Recovery in Different Time-points

Phototherapy Clinical Trial

Official title:

Effects of Photobiomodulation Therapy (PBMT) on Muscular Performance and Recovery in Different Time-points

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03420391
• Other study ID #: 113553
• Status: Completed
• Phase: N/A
• Start date: May 20, 2019
• Est. completion date: July 19, 2019

Study information

• Verified date: April 2020
• Source: University of Nove de Julho
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Recent studies with photobiomodulation therapy (PBMT) have shown positive results delaying skeletal muscle fatigue and improving the status of biochemical markers related to skeletal muscle damage when these therapies were applied before exercise. The aim of this project is to verify the effects of PBMT in improvement of skeletal muscle performance and skeletal muscle recovery in healthy male subjects. This project aim also to validate the concept that simultaneous use of three wavelengths and light sources lead to optimized action independently of time-window between irradiation and the exercise.

Description:

This is a randomized, triple-blinded, placebo-controlled trial. Sixty healthy untrained male subjects will be randomly allocated to six experimental groups: Placebo, Control, PBMT 5 mins, PBMT 3h, PBMT 6h and PBMT 24 hours. PBMT will be applied precisely two minutes after baseline MVC test. Then, after five minutes, 3, 6 hours or 1 day (24 hours) of PBMT the eccentric exercise protocol will be performed. We will analyze maximum voluntary contraction (MVC), creatine kinase (CK) activity and delayed onset muscle soreness (DOMS). Assessments will be performed at baseline, immediately after (1 minute), 1 hour, 24 and 48 hours after the eccentric exercise protocol.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: July 19, 2019
• Est. primary completion date: July 19, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Healthy

• not athletes or who engage in physical activity at most once a week

• Individuals should not present a history of musculoskeletal injury in the hip and knee regions in the two months prior to the studies

• they should not be using pharmacological agents and / or nutritional supplements

• They must attend 100% of the data collections.

Exclusion Criteria:

• Individuals who do not meet the criteria mentioned above or who present musculoskeletal damage during collection were excluded from the study.

Related Conditions & MeSH terms

• Phototherapy

Intervention

Device:
• Photobiomodulation Therapy (PBMT)
Phototherapy device - Multi Radiance Medical® (Solon, OH, EUA)

Locations

Country	Name	City	State
Brazil	Universidade Nove de Julho	São Paulo

Sponsors (3)

Lead Sponsor	Collaborator
University of Nove de Julho	Fundação de Amparo à Pesquisa do Estado de São Paulo, University of Bergen

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Torque peak / maximum voluntary contraction - MVC	Assessment was performed in the isokinetic dynamometer (System 4, Biodex®, USA)	1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.
Secondary	Delayed onset muscle soreness (DOMS)	Assessment was performed through visual analogue scale (VAS). A visual analogue scale (VAS) of 100 mm was used as a self-rating of volunteers DOMS intensity, with assistance of a blinded researcher, where "0" corresponds to no pain and 100mm corresponds to the worst pain possible.	1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.
Secondary	Biochemical marker of muscle damage	Analysis of Creatine Kinase (CK) levels	1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.