Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal Women

Photoaging Clinical Trial

Official title:

Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal Women

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04869852
• Other study ID #: MANGO_02
• Status: Not yet recruiting
• Phase: N/A
• Start date: May 30, 2021
• Est. completion date: June 30, 2023

Study information

• Verified date: May 2021
• Source: Integrative Skin Science and Research
• Contact: Raja Sivamani, MD, MS, AP
• Phone: 9165241216
• Email: raja.sivamani[@]integrativeskinresearch.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Mangos are a rich source of nutrients such as carotenoids, vitamin C and fiber, as well as polyphenols and phenolic acids such as mangiferin, ellagic acid, and gallotannins. Mango extract has been reported to protect against photo-aging of the skin in an animal model exposed to UVB radiation, reducing the length of wrinkles and increasing collagen bundles. Beta-carotene and other carotenoids are known to provide skin protection from sunlight, but other compounds in mangos, may also be important in reducing oxidative damage in aging skin.

We have recently completed a pilot study showing a clear trend in skin wrinkle reduction when postmenopausal women consumed 85g of Ataulfo mangos, four times per week for 16 weeks. To confirm and extend these results, a larger study is proposed.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 70
• Est. completion date: June 30, 2023
• Est. primary completion date: June 30, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 50 Years to 70 Years

Eligibility

Inclusion Criteria:

• 50 - 70 years old

• Postmenopausal

• Fitzpatrick skin type I, II, or III

• BMI 18.5 - 35

• Must be willing to comply with all protocol requirements

• Must be willing to have flash photo facial images taken with the imaging systems

Exclusion Criteria:

• Smokers

• Allergy to mangos

• Vegans/vegetarians

• Adults unable to consent

Related Conditions & MeSH terms

• Photoaging

Intervention

Other:
• Food
85g mango, 4x/week

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Integrative Skin Science and Research	National Mango Board

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Wrinkles	Wrinkle score measured by Facial Image Analysis System	week 20
Secondary	Facial Hydration	Moisture measured by MoistureMeterSC	week 20
Secondary	Facial Redness	Redness measured by Facial Image Analysis System	week 20
Secondary	Facial Elasticity	measured by Cutometer	week 20
Secondary	Gut microbiome	analyze for changes in gut microbiome diversity measures (Shannon Diversity)	week 20
Secondary	Gut microbiome	Analyze for the relative abundance of short chain fatty acid producing bacteria	week 20