Efficacy & Safety of Profile HaloTM Mixed Fractional Laser on Treating of

Status Completed

Clinical Trial Summary

1. Fractional laser has become an important laser modality in management of a number of skin conditions and photoaging. Fractional photothermolysis is the fractional emission of light into microscopic treatment zones, creating small columns of injury to the skin in a pixilated fashion. Epidermal and dermal disruptions occur in these focal zones of thermal injury, stimulating dermal collagen production and elastic tissue formation. Fractional laser has been used successfully to treat photodamage and overall dyschromia in the Caucasian population. However, there is not much improvement in Asian population.

2. Photoaging refers to the skin caused by intense and chronic exposure to sunlight. The visible effects of photoaging are fine wrinkles, mottling, pigmentation and roughness of the skin. These changes are usually associated with chronologic aging. However, photoaging is not a good indicator of chronologic age. It just makes a person look older than his or her chronologic age. Skin ageing may be divided into two processes: intrinsic ageing and extrinsic ageing (or photoageing). Both are accompanied by changes in the morphological and biomechanical properties of skin.

3. Profile HaloTM dual-wavelength fusion fractional laser is the first hand tool in the world that integrates ablative and non-ablative fractional lasers. It includes a non-ablative fractional laser with a wavelength of 1470nm and an ablative fractional laser with a wavelength of 2940nm. A day after treatment, new epithelial tissue began to appear, and the necrotic epidermis formed microepidermal necrotic debris (MENDs). MENDs were surrounded by keratin 2-7 days after treatment, and collagen sequence in MTZs was changed 7 days later. The 2940 ablative fractional laser can be added with 20-100 micron lattice stripping, ensuring safety while enabling MENDs to be peeled off 2 days earlier and reducing the risk of side effects. This makes the laser safe and effective compared with the single fractional laser and reduces the downtime.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03948945
Study type	Interventional
Source	Xijing Hospital
Contact
Status	Completed
Phase	N/A
Start date	October 1, 2015
Completion date	October 1, 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05271136` - A Clinical Study to Evaluate the Efficacy of an Anti-Aging Serum	N/A
Completed	`NCT05514782` - A Clinical Study to Evaluate the Long-Term Efficacy and Tolerability of a Daily Anti-Aging Daily Serum	N/A
Completed	`NCT04911374` - An Open-Label Clinical Study to Evaluate the Efficacy of a Face Cream and Eye Cream	N/A
Completed	`NCT04586816` - Randomized, Double-Blind Evaluation of Maple Leaf Extract (Maplifa) for Photoaging	N/A
Not yet recruiting	`NCT05004909` - Effectivity of 1 Finger Tip Unit Compared to 2 Finger Tip Units 0.05% Tretinoin Cream	N/A
Completed	`NCT05039723` - Xeomin, Radiesse, and Belotero Facial/Neck Rejuvenational	Phase 4
Completed	`NCT06366503` - Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional Ablative CO2 Laser for Facial Rejuvenation	N/A
Completed	`NCT05027282` - Safety and Effectiveness of the CLEAR + BRILLIANT TOUCH(R) Diode Laser 1440-nm and 1927-nm Combination Wavelength Treatment	N/A
Not yet recruiting	`NCT06096649` - The Effects of Zinc Di-(Dibutyryl Lisinate) on Skin Health and the Skin Microbiome in Photoaged Skin	N/A
Completed	`NCT03661697` - Combination Versus Laser Treatment Only	N/A
Completed	`NCT06148558` - A Twelve Week Clinical Study to Evaluate the Efficacy and Tolerability of a Sunscreen Moisturizer SPF 50+	N/A
Enrolling by invitation	`NCT06188338` - A 56-day Clinical Study on Facial Skin Rejuvenation	N/A
Recruiting	`NCT06195605` - Investigating Age Dependence of Fibroblast and Extracellular Matrix Responses to Cross-linked Hyaluronic Acid Filler in Human Skin	N/A
Not yet recruiting	`NCT04869852` - Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal Women	N/A
Not yet recruiting	`NCT02126644` - The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Photoaging	Phase 2
Active, not recruiting	`NCT01372566` - Effect of Platelet Rich Plasma on Photoaged Skin	Phase 1/Phase 2
Unknown status	`NCT00842907` - Efficacy and Safety of Oral Isotretinoin for Cutaneous Photodamage	Phase 2
Completed	`NCT03112863` - Comparison of the Cosmetic Effects of Bakuchiol and Retinol	Early Phase 1
Recruiting	`NCT05386368` - RECELL to Promote Healing Following Carbon Dioxide (CO2) Laser Treatment in Cosmetic Patients	Phase 4
Recruiting	`NCT05471947` - TCA 15% Chemical Peel for Improvement in Hand Lentigines	Phase 4

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Efficacy and Safety of Profile HaloTM Mixed Fractional Laser on Treating of Facial and Neck Photoaging.

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms