PKU Skin Stripping

Status Completed

Clinical Trial Summary

PURPOSE OF STUDY: To determine if a non-invasive skin stripping technique can be used to detect individuals with phenylalanine abnormalities, and to monitor dietary and/or drug effects over time.

Clinical Trial Description

This study will determine if a non-invasive skin stripping technique can be used to detect individuals with phenylalanine abnormalities, and to monitor dietary and/or drug effects over time. To do this 50 children and adults with phenylalanine abnormalities and up to 50 unaffected controls will be recruited to this study. The 50 affected individuals will have their metabolomic profile analyzed from up to 3 skin-stripping samples over time and compared to their serum amino acid profile in both dried blood spots and a typical blood sample. The unaffected controls will provide one skin-stripping sample. Clinical data regarding compliance with dietary therapy and other medications will be collected to determine other effects on the metabolome. ;

Study Design

Related Conditions & MeSH terms

Phenylketonurias

Clinical Trial Details

NCT number	NCT04368624
Study type	Observational
Source	Children's Hospital Medical Center, Cincinnati
Contact
Status	Completed
Phase
Start date	October 12, 2015
Completion date	April 2021

View Details

See also
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