Stroke Clinical Trial
Official title:
A Study of Genetic Variants Associated With Enalapril-Induced Adverse Drug Reaction and Impact of Pharmacogenomics on First Stroke in Hypertensive Patients Taking Enalapril or Enalapril-Folic Acid Therapy.
Dry cough is the most common adverse reaction of angiotensin converting enzyme, including
enalapril, in Chinese population. Clinical observations suggest that the incidence of
ACEI-induced dry cough is different between Chinese and other racial groups, however, there
is still lack of research data in Chinese. Stroke is the second leading cause of death in the
world and leading cause of death in China. Except the known risk factor such as hypertension,
high homocysteine level, folic acid deficiency, the impact of genetics should not be ignored.
In this study, we will investigate whether there are specific genotypes which may predict the
incidence of (1)enalapril-induced dry cough in Chinese and (2)first stroke in hypertensive
patients taking enalapril or enalapril-folic acid therapy, so as to provide a basis for
developing guidelines on precision medication in enalapril therapy apply to Chinese
population.
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