Peritoneal Metastases Clinical Trial
Official title:
Feasibility of the LUM Imaging System for Detection of Peritoneal Surface Malignancies
The objective of this feasibility study is to assess the initial safety and efficacy of the LUM Imaging System for in vivo imaging of metastases to the peritoneum from primary gastrointestinal cancer, ovarian cancer and mesothelioma. This feasibility study consists of two parts: (a) a dose escalation phase to select the optimal dose followed by (b) enrollment of additional patients to develop the tumor detection algorithm.
Subjects will be recruited and screened at a single institution, Massachusetts General Hospital. All subjects will have an established diagnosis of metastases to the peritoneum from primary colonic, appendiceal, or ovarian cancer or mesothelioma and are scheduled for surgical debulking. This study consists of a dose escalation and timepoint evaluation phase and an evaluation and improvement phase following tumor detection algorithm development. 30 patients will be enrolled into this study. 18 into a dose escalation arm and 12 in the algorithm development phase. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03422432 -
Prophylactic HIPEC for Colorectal Cancers at High Risk of Developing Peritoneal Metastases
|
N/A | |
| Not yet recruiting |
NCT06295094 -
The Efficacy of PIPAC and Minimally Invasive Radical Resection in High-risk Gastric Cancer Patients.
|
Phase 2 | |
| Recruiting |
NCT05056389 -
Normothermic Intraperitoneal Chemotherapy - Long Term in Peritoneal Metastases From Colorectal Cancer (NIPEC-OXA)
|
Phase 1 | |
| Withdrawn |
NCT03682744 -
CAR-T Intraperitoneal Infusions for CEA-Expressing Adenocarcinoma Peritoneal Metastases or Malignant Ascites (IPC)
|
Phase 1 | |
| Recruiting |
NCT06367270 -
The Application of Pressured Intraperitoneal Aerosol Chemotherapy (PIPAC) for Peritoneal Surface Malignancies
|
Phase 2 | |
| Recruiting |
NCT05623787 -
Diagnostic Value of Diffusion-weighted Magnetic Resonance in High-risk Colorectal and Appendiceal Neoplasms
|
N/A | |
| Not yet recruiting |
NCT05095467 -
HIPEC-AS in Patients With Peritoneal Metastasis of the Stomach or Esophagogastric Junction
|
Phase 2 | |
| Completed |
NCT04083547 -
Circulating Tumour Cells in Patients With Peritoneal Metastases
|
||
| Recruiting |
NCT06216561 -
Intraperitoneal LSTA1 in CRS-HIPEC
|
Phase 1 | |
| Recruiting |
NCT05277766 -
Intraperitoneal Aerosolized Nanoliposomal Irinotecan (Nal-IRI) in Peritoneal Carcinomatosis From Gastrointestinal Cancer
|
Phase 1 | |
| Not yet recruiting |
NCT05318794 -
Neoadjuvant Systemic and Peritoneal Chemotherapy for Advanced Gastric Cancer
|
Phase 2 | |
| Completed |
NCT05665257 -
Feasibility of Preoperative Inspiratory Muscle Training for Patients With Peritoneal Metastases
|
N/A | |
| Terminated |
NCT05581719 -
A Phase 1/2a Study Evaluating Allocetra-OTS as Monotherapy or in Combination With Anti-PD-1 Therapy for the Treatment of Advanced Solid Tumor Malignancy
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05379790 -
Concomitant Intraperitoneal and Systemic Chemotherapy in Patients With Extensive Peritoneal Carcinomatosis of Gastric Origin
|
Phase 1 | |
| Recruiting |
NCT04956068 -
PIPAC for Peritoneal Metastases
|
Phase 1 | |
| Recruiting |
NCT05204173 -
Efficacy and Safety of Sintilimab Combined Intraperitoneal and Intravenous Paclitaxel Plus Oral S-1 in Gastric Cancer Patients With Peritoneal Metastasis
|
Phase 2 | |
| Recruiting |
NCT04861558 -
Efficacy of Hyperthermic Intraperitoneal Chemotherapy
|
Phase 3 | |
| Recruiting |
NCT05340569 -
Diagnostic Value of DWI-MRI for Detection of Peritoneal Metastases in High-risk Pancreatic Ductal Adenocarcinoma.
|
N/A | |
| Not yet recruiting |
NCT04744688 -
Changes in Coagulation in Colorectal Cancer Patients Undergoing Surgical Treatment
|
||
| Completed |
NCT03733184 -
Development of an IDEAL Framework to Standardise Cytoreductive Surgery for Colorectal Peritoneal Metastases
|