Fallopian Tube Cancer Clinical Trial
Official title:
Overcoming Chemoresistance in Advanced Ovarian Cancer Via Targeting Hypoxia
The goal of this non-randomized prospective study is to use 18F-EF5-PET/CT imaging to
identify and locate intraabdominal hypoxic ovarian cancer lesions. With targeted surgical
sampling, precisely obtain hypoxic and potentially chemoresistant cancer tissue for our
analyses and identify key molecular differences between hypoxic and non-hypoxic tumors within
the same patient.
A portion of advanced stage EOC are inoperable at diagnosis and can be treated with
neoadjuvant chemotherapy (NACT) before surgery. This approach offers a unique opportunity to
study how hypoxic tumor areas respond to treatment.
MORE SPECIFIC AIMS
1. To validate the feasibility of PET-tracer EF5 in EOC imaging.
- Quantify the amount and exact locations of hypoxic tumors in EOC patients using
herein developed protocol and tracers (18F-EF5 and 18F-FDG) in diagnostic and
neoadjuvant settings.
- Measure the non-cancer related EF5 accumulation spots and establish the potential
pitfalls in abdominal EF5 imaging
- Establish a method to verify hypoxic locations with 18F-EF5-PET/CT information
during the operation.
- Develop and validate a model that predicts chemotherapy response based on
functional imaging information.
2. To reveal hypoxia related alterations in collected tissue samples (i.e. altered DNA
damage repair, altered mitochondrial respiratory functioning, overexpression of hypoxia
response elements etc)
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