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Clinical Trial Summary

IMGN853-0420 is a multicenter, open-label, phase 2 study of carboplatin plus mirvetuximab soravtansine followed by mirvetuximab soravtansine continuation in folate receptor-alpha positive, recurrent platinum sensitive, high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancer following 1 prior line of platinum-based chemotherapy.


Clinical Trial Description

This Phase 2 study is designed to evaluate the efficacy and safety of MIRV in combination with carboplatin followed by MIRV continuation in FRα-positive patients with recurrent platinum-sensitive ovarian cancer (PSOC) following 1 prior line of platinum-based chemotherapy. Upon completion of carboplatin plus MIRV combination chemotherapy (6 cycles), patients without progressive disease will continue on single-agent MIRV. Patients must have confirmation of FRα positivity by the Ventana FOLR1 Assay. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05456685
Study type Interventional
Source ImmunoGen, Inc.
Contact ImmunoGen, Inc.
Phone 781-895-0600
Email medicalaffairs@immunogen.com
Status Recruiting
Phase Phase 2
Start date September 28, 2022
Completion date December 31, 2026

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