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Clinical Trial Summary

Prevalence of PAD and osteoporosis (OP) both get higher with age. Clinical and epidemiologic evidence have showed an increased cardiovascular risk in OP and bone loss and fragility fractures in patient with cardiovascular disease. This study will examine the relationship between vascular disease in legs and sBMD and vBMD at trabecular and cortical sites and bone microarchitecture.

Clinical Trial Description

The primary goal of our study is to determinate if presence of PAD is associated with lower sBMD and vBMD values at the tibias, assuming that BMD should be more alterate in the predominant vascular impairement site. Our secondary objectives are to : - determine if severity of PAD quantified by ankle brachial index ABI is associated to a decrease of BMD values defined by T-Score at the left hip, spine and legs, but also with volumetric values, assessed by HRpQCT at the non dominant radius and at both tibias. - determine the prevalence of osteoporosis in our population - To evaluate the relationships between ; - lipids and bone parameters - vit D and parathormone with PAD severity - levels of physical activity and both vascular and bone impairments ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05034848
Study type Interventional
Source Centre Hospitalier Régional d'Orléans
Contact Aurélie DESPUJOLS
Phone +33238744071
Email [email protected]
Status Recruiting
Phase N/A
Start date March 31, 2021
Completion date September 2022

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