Peripheral Artery Disease (PAD) : Its Effects on Bone — AMICOS  

Peripheral Artery Disease Clinical Trial

Official title: Peripheral Artery Disease (PAD) : Its Effects on Bone

Status Terminated

Clinical Trial Summary

Prevalence of PAD and osteoporosis (OP) both get higher with age. Clinical and epidemiologic evidence have showed an increased cardiovascular risk in OP and bone loss and fragility fractures in patient with cardiovascular disease.

This study will examine the relationship between vascular disease in legs and sBMD and vBMD at trabecular and cortical sites and bone microarchitecture.

Clinical Trial Description

The primary goal of our study is to determinate if presence of PAD is associated with lower sBMD and vBMD values at the tibias, assuming that BMD should be more alterate in the predominant vascular impairement site.

Our secondary objectives are to :

• determine if severity of PAD quantified by ankle brachial index ABI is associated to a decrease of BMD values defined by T-Score at the left hip, spine and legs, but also with volumetric values, assessed by HRpQCT at the non dominant radius and at both tibias.

• determine the prevalence of osteoporosis in our population

• To evaluate the relationships between ;

• lipids and bone parameters

• vit D and parathormone with PAD severity

• levels of physical activity and both vascular and bone impairments ;

Related Conditions & MeSH terms

• Bone
• Peripheral Arterial Disease
• Peripheral Artery Disease

• NCT number: NCT05034848
• Study type: Interventional
• Source: Centre Hospitalier Régional d'Orléans
• Status: Terminated
• Phase: N/A
• Start date: March 31, 2021
• Completion date: May 19, 2021