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Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery — PROTECT  

Surgery--Complications Clinical Trial

Official title:
Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery

Clinical Trial Summary

We propose to test the hypothesis that aggressive warming reduces the incidence of major cardiovascular complications, compared to routine care. Half of the participants will be randomly assigned to routine care (core temperature ≈35.5°C), while the other half will receive aggressive warming (>37°C core temperature) in a multi-center trial.

Clinical Trial Description

Hypothermia increases sympathetic activation, promotes tachycardia, and causes hypertension - all of which may increase the risk of myocardial injury. Moderate perioperative hypothermia is now uncommon, but mild hyperthermia (≈35.5°C) remains common. Whether aggressive warming to a truly normothermic level (≈37°C) improves outcomes remains unknown. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03111875
Study type Interventional
Source The Cleveland Clinic
Contact
Status Completed
Phase N/A
Start date March 27, 2017
Completion date May 17, 2022
View Details
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