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NCT06354504 Clinical Trial

Bactericidal Permeability Protein Inhibitor and Interleukin-1beta Levels After Non-surgical Periodontal Treatment

Periodontitis Clinical Trial

Official title:
Gingival Crevicular Fluid (GCF) Bactericidal/Permeability-increasing Protein (BPI) and Interleukin (IL)-1beta in Periodontitis Patients: Non-surgical Periodontal Treatment Effects

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT06354504
Other study ID # 20.02.2019/177
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date November 19, 2019
Est. completion date September 20, 2020

Study information
Verified date April 2024
Source Akdeniz University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival crevicular fluid (GCF) levels of bactericidal/permeability-increasing protein (BPI) and interleukin-1beta (IL-1ß).

Description:

Bactericidal/permeability-increasing proteins (BPI) specific and powerful effect against Gram negative bacteria and their LPSs is completely observable in biological fluids such as plasma, serum, and whole blood. Objective: It is the evaluation of periodontal disease effect of BPI and interleukin-1 beta (IL-1 β) levels in gingival fluid before and after non-surgical periodontal treatment (NSPT)in patients with periodontal disease. Method: Thirty systemically healthy and non-smoking individuals with periodontitis were included in the study. Before NSPT, the clinical parameters of plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAS), bleeding on probing (BOP) were measured. The gingival fluid samples were taken using the paper strip method. The same procedures were repeated at 6 weeks and 6 months after non-surgical periodontal treatment. ELISA method was used for the analysis of the samples

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date September 20, 2020
Est. primary completion date September 20, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 22 Years to 64 Years
Eligibility Inclusion Criteria Systemically healthy, - Stage II or III, Grade A periodontitis - Having at least 20 permanent teeth (excluding third molars and any tooth loss induced by -non-periodontal causes). Exclusion Criteria: Smoking, - use of alcohol; pregnancy or lactation; intake ofantibiotics, steroidal or non-steroidal anti-inflammatory drugs within the last 6 months - having received periodontal treatment within the last 6 months

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Non-surgical periodontal treatment
Scaling and root planing in two sessions over the course of a 48-hour period comprised the standard treatment procedure

Locations
Country Name City State
Turkey Akdeniz Üniversitesi Dis Hekimligi Fakültesi Antalya
Turkey Akdeniz Üniversity Antalya

Sponsors (1)
Lead Sponsor Collaborator
Akdeniz University

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Gingival crevicular fluid Bactericidal/permeability-increasing proteins levels Gingival Crevicular Fluid Bactericidal Permeability Increasing Protein levels in periodonitis patients after Non-surgical periodontal treatment through study completion, an average of 1 year
Secondary Gingival crevicular fluid interleukin-1Beta levels Gingival Crevicular Fluid IL-1ß in periodonitis patients after Non-surgical periodontal treatment through study completion, an average of 1 year
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