Periodontitis Clinical Trial
Official title:
Gingival Crevicular Fluid(GCF) Bactericidal Permeability Protein (BPI) and Interleukin(IL)-1 Beta Levels and Relationship With Periodontal Disease
Verified date | March 2024 |
Source | Akdeniz University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Objective: The aim of this study is to determine the amounts of BPI (Bactericidal permeability protein) and interleukin-1beta (IL-1β) in gingival fluid samples obtained from individuals with periodontally healthy and periodontal disease, to compare these amounts between study groups, and to evaluate their relationship with clinical parameters. In cases where clinical parameters increase, IL-1β amounts also increase significantly. The amount of IL-1β in individuals with periodontal disease is significantly higher compared to healthy individuals. There is positive correlation between BPI and clinical parameters. The amount of BPI in individuals with periodontal disease is significantly higher than in healthy individuals. More studies are needed to better understand the importance and therapeutic effect of BPI in periodontitis
Status | Completed |
Enrollment | 100 |
Est. completion date | January 20, 2020 |
Est. primary completion date | November 25, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: 1. For the periodontitis group, intraoral examination shows inflammation in the gums, supragingival and by observing the formation of subgingival tartar and microbial dental plaque and pockets, Diagnosis of periodontitis means that there is a vertical or detection of horizontal bone loss (Periodontitis group), 2. Failure to observe the presence of periodontal pockets, vertical and horizontal no bone destruction, bleeding score on full-mouth probing below 10 percent (Healthy group), 3. Agreeing to participate in the research and filling out and signing the voluntary consent form. Exclusion Criteria: 1. Pregnant and lactating individuals, 2. Individuals who smoke, 3. Individuals with any systemic disease, 4. Individuals who have received periodontal treatment in the last 6 months, 5. Individuals who have used antibiotics in the last 6 months 6. Individuals in whom local factors that increase destruction such as fillings and crowns are observed in areas with periodontal pocket formation. |
Country | Name | City | State |
---|---|---|---|
Turkey | Akdeniz Üniversitesi Dis Hekimligi Fakültesi | Antalya |
Lead Sponsor | Collaborator |
---|---|
Akdeniz University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Gingival Crevicular Fluid Bactericidal Permeability Increasing Protein levels in periodonitis | Protein levels that increase gingival crevicular fluid bactericidal permeability are expected to increase in the periodontitis group. | through study completion, an average of 1 year |
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