Hydroxyapetite Nanoparticles, Tricalcium Phosphate Nanoparticles, and PRF for Treatment of Gingival Recession

Periodontitis Clinical Trial

Official title:

Comparative Study Between Hydroxyapetite Nanoparticles and Tricalcium Phosphate Nanoparticles Loaded on Platelet Rich Fibrin Membranes for Treatment of Gingival Recession

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06016894
• Other study ID #: khafrelsheikh university
• Status: Completed
• Phase: N/A
• Start date: September 1, 2000
• Est. completion date: April 22, 2023

Study information

• Verified date: August 2023
• Source: October 6 University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the present study was to compare between nanocrystalline hydroxyapatite and tricalcium phosphate carried on PRP membrane in treatment of Miller's class 1 gingival recession in human.

Description:

gingival recession (GR) is apical movement of the gingival margin beyond the cement-enamel junction. The use of free gingival grafts, sliding pedicle grafts, subepithelial connective tissue grafts, envelope or tunnelling techniques, the use of acellular dermal, connective tissue allografts, guided tissue regeneration, Platelet rich fibrin (PRF), and coronally advanced flap (CAF) are the surgical methods that have been developed to treat gingival recession. For treatments of intrabony defects, a synthetic nanocrystalline hydroxyapatite (NcHA) bone graft has been introduced. Osteoconductivity, bioresorbability, and close contact are benefits of NcHA material. Critical size defects showed quick healing when the NcHA was utilised as a bone graft alternative. NcHA binds to bone and increases osteoblast activity to promote bone regeneration. A promising bone replacement material, tricalcium phosphate (TCP) is known for its strong bioactivity and resorbable qualities. Tricalcium phosphate (TCP) is one of the most popular and effective artificial bone substitutes. It is osteoinductive as well as osteoconductive. These characteristics enable full bone defects regeneration together with its cell-mediated resorption. In this study, we compared between nanocrystalline hydroxyapatite and tricalcium phosphate carried on PRP membrane in treatment of Miller's class 1 gingival recession in human.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: April 22, 2023
• Est. primary completion date: September 20, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 45 Years

Eligibility

Inclusion Criteria:

• Patients with good systemic health and no contraindication for periodontal surgery.

• Patients who are able to maintain good oral hygiene.

• Gingival thickness for the site selected should be =1mm.

• The height of keratinized gingiva (HKG) for the site selected should be =1 mm (HKG is the distance between the most apical point of the gingival margin and the mucogingival junction).

Exclusion Criteria:

• Active infectious diseases (hepatitis, tuberculosis, HIV, etc….).

• Medically compromised patients.

• Patients taking medications known to cause gingival enlargement.

• Pregnant patients and smokers.

• Previous mucogingival surgery at the defect.

• Restorations or caries in the area to be treated and non vital tooth.

• Teeth which are tilted or rotated.

Related Conditions & MeSH terms

• Gingival Recession
• Periodontitis

Intervention

Procedure:
• coronally advanced flap
coronally advanced flap operation

Other:
• Nanocrystalline hydroxyapatite loaded in PRF
Nanocrystalline hydroxyapatite loaded in PRF
• Nanocrystalline tricalcium phosphate loaded in PRF
Nanocrystalline tricalcium phosphate (NcTCP) loaded in PRF

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
October 6 University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Recession height	measurement recession height	6 months
Primary	Recession width	measurement of Recession width	6 months
Primary	Height of the keratinized tissue	measurement of Height of the keratinized tissue	6 months
Primary	Percentage of root coverage	It is calculated after 1, 3, 6 months as [RH preoperative - RH postoperative]/RH preoperative) x 100%.	6 months
Primary	Radiographic assessment	measurement of buccal bone gain	6 months
Secondary	Probing pocket depth	measurement of Probing pocket depth	6 months
Secondary	Clinical attachment level	measurement of Clinical attachment level	6 months