Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT05924828 |
| Other study ID # |
atauniperio3 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
August 1, 2023 |
| Est. completion date |
December 1, 2023 |
Study information
| Verified date |
January 2024 |
| Source |
Ataturk University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
The goal of this observational study is to compare saliva sTREM-1, sTREM-2, Presepsin levels
and sTREM-1/sTREM-2 ratio of participants with/without periodontitis.
The main question it aims to answer is there a relationship between saliva sTREM-1, sTREM-2,
Presepsin levels, sTREM-1/sTREM-2 ratio and periodontitis.
Participants will give saliva samples without any intervention
Description:
Periodontitis is a chronic, inflammatory disease with a cyclical course with active and
passive periods, which may result in the destruction of gingival fibers, resorption of
alveolar bone, and subsequent tooth loss, by spreading the inflammatory event that started in
the gingiva to the tissues supporting the tooth as a result of the effects of bacteria. The
disease is closely associated with many systemic conditions. These conditions include
diabetes, cardiovascular diseases, respiratory diseases, birth complications, pregnancy,
puberty.
sTREM-1, the soluble form of TREM-1 resulting from the cleavage by MMP (matrix
metalloproteinase) of the extracellular portion of this receptor, was identified in 2004.
Higher concentrations of sTREM-1 were noted in gingival crevicular fluid (GCF) and saliva
from patients with periodontitis and correlated with certain periodontal clinical parameters
(Plaque Index [PlI], Gingival Index [GI], PPD or clinical attachment loss [CAL]). TREM-2,
another member of the TREM family, is also synthesised by macrophages and together with its
receptor, DNAX-activating protein of 12 kDa (DAP12), functions to suppress the
proinflammatory response. Initial studies with TREM-2 in microglia cells showed that it plays
an important role in suppressing TNF-α and IL-6 levels. The secretion of presepsin has been
reported as a stimulus of monocytes phagocytosis. Therefore, recognition of presepsin is
predictable even in healthy non-infective individuals. The concept for presepsin proposes
that its levels should be measureable in non-infective individuals, increase the early steps
of bacterial infections, and its levels should be dependent on the intensity of the innate
immune induction.
The study material will be 70 adult individuals who applied to Atatürk University Faculty of
Dentistry, Department of Periodontology for different reasons {1. group (H): periodontally
healthy individuals, group 2 (P): individuals with periodontitis}. Saliva samples will be
collected from the participants without any periodontal intervention. sTREM-1, sTREM-2,
Presepsin levels will be studied.
The aim of this study; to evaluate the saliva sTREM-1, sTREM-2, Presepsin levels and
sTREM-1/sTREM-2 ratio in the saliva samples of patients with periodontitis by comparing them
with healthy controls, and to investigate the association in the pathogenesis of
periodontitis or a simple marker of disease activity in the light of these findings.
