Treatment Of Shallow Periodontal Pockets Using PRF As an Adjunct To Scaling And Root Planing In Periodontitis Patients

Periodontitis Clinical Trial

Official title:

Treatment Of Shallow Periodontal Pockets Using PRF As an Adjunct To Scaling And Root Planing In Periodontitis Patients, Randomized Clinical Trial

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05890157
• Other study ID #: PRF as adjunct to ScRp
• Status: Not yet recruiting
• Phase: N/A
• Start date: July 30, 2023
• Est. completion date: December 30, 2023

Study information

• Verified date: May 2023
• Source: University of Baghdad
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Platelet rich fibrin (PRF) has been widely used in regenerative dentistry since it provides plenty amount of growth factors that enhance wound healing and tissue regeneration. Platelet derived growth factor-BB (PDGF-BB) is a growth factor with essential functions such as regulation of cell migration, proliferation, and differentiation. This study aims to evaluate the efficacy of PRF in improving the clinical periodontal parameters and GCF level of PDGF-BB.

Description:

Split mouth randomized clinical trial is the design of the study. 12 periodontitis patients with 24 opposite shallow periodontal pockets (4-6 mm in depth) will be selected. Randomization in this study will be achieved using toss of coin method in which periodontal pockets will be designated either control site or test site. PRF will be used as an adjunct to scaling and root planing to treat the test sites. While control sites were treated by scaling and root planing only. Clinal periodontal parameters were recorded and GCF level of PDGF-BB will be measured at baseline and1- and 3- month follow-up visits to evaluate the healing response to the treatment.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 12
• Est. completion date: December 30, 2023
• Est. primary completion date: November 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 70 Years

Eligibility

Inclusion Criteria:

•periodontitis

Exclusion Criteria:

• Periodontal therapy for the last 3 months

• Medical history of systemic diseases such as diabetes.

• Patients wearing dental prosthesis

• Alcoholic patients

• Teeth with grade II mobility, endodontic lesions, and teeth with untreated caries

Related Conditions & MeSH terms

• Periodontal Pocket
• Periodontitis

Intervention

Other:
• PRF
Split mouth randomized clinical trial will be the design of the study. 12 periodontitis patients with 24 opposite shallow periodontal pockets (4-6 mm in depth) will be selected. Randomization in this study will be achieved using toss of coin method in which periodontal pockets were designated either control site or test site. PRF will be used as an adjunct to scaling and root planing to treat the test sites. While control sites will be treated by scaling and root planing only. Clinal periodontal parameters will be recorded and GCF level of PDGF-BB will be measured at baseline and1- and 3- month follow-up visits to evaluate the healing response to the treatment.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Baghdad

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Clinical attachment level	Using UNC-15 periodontal probe measured in mm	Change from baseline to 1-month and change from baseline to 3-month
Primary	Change in Periodontal pocket depth measured in mm	Using UNC-15 periodontal probe measured in mm	Change from baseline to 1-month and change from baseline to 3-month
Secondary	Change in plaque index	Using Sinless and Loe 1964 plaque index scores	Change from baseline to 1-month and change from baseline to 3-month
Secondary	Change in bleeding on probing percentage	Using UNC-15 periodontal probe	Change from baseline to 1-month and change from baseline to 3-month
Secondary	Change in GCF level of platelet derived growth factor	Using periocol paper to collect GCF and analysed by ELISA test	Change from baseline to 1-month and change from baseline to 3-month