Adjunctive Use Of A Novel Hyaluronic Acid/Chlorhexidine Gel In The Non Surgical Treatment Of Periodontitis

Periodontitis Clinical Trial

Official title:

Adjunctive Use Of A Novel Hyaluronic Acid/Chlorhexidine Gel In The Non Surgical Treatment Of Periodontitis: A Split Mouth Randomized Controlled Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05682833
• Other study ID #: REC-22-02-26-S
• Status: Recruiting
• Phase: N/A
• Start date: October 1, 2022
• Est. completion date: June 20, 2024

Study information

• Verified date: January 2023
• Source: University of Sharjah
• Contact: Prof. Zahi Badran Prof.
• Phone: +97165057353
• Email: zbadran[@]sharjah.ac.ae
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

General Objective :

To evaluate the outcome of non surgical periodontal therapy with local drug delivery adjunct to scaling and root planning

Specific Objective :

To determine the effect of intra-pocket application of hyaluronic acid /chlorohexidine gel in non surgical periodontal treatment on clinical periodontal parameters and microbiological level .

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: June 20, 2024
• Est. primary completion date: December 20, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 60 Years

Eligibility

Inclusion Criteria:

• Age : 20-60 years old

• At least 20 remaining teeth

• Periodontitis stage III and IV ,Grade A, B and C

Exclusion Criteria:

• Patients taking specific medications: antibiotic , anticoagulants or anti-inflammatory

• Previous periodontal therapy in the past 3-6 months.

• Immunocompromised patients

• Systemically diseased patients: Diabetes ,osteoporosis etc

• History of allergies or hypersensitivity reactions to chlorohexidine or Hyaluronic acid

• Pregnant or lactating women.

• Heavy Smokers (more than 20/day)

Related Conditions & MeSH terms

• Chlorhexidine
• Hyaluronic Acid
• Periodontitis

Intervention

Procedure:
• Non surgical periodontal therapy
Subgingival ultrasonic debridement + manual root planning

Locations

Country	Name	City	State
United Arab Emirates	University Dental Hospital Sharjah	Sharjah

Sponsors (1)

Lead Sponsor	Collaborator
University of Sharjah

Country where clinical trial is conducted

United Arab Emirates, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	pocket depth		2 months
Primary	Bleeding on Probing		2 months
Primary	Clinical attachment level		2 months
Secondary	Plaque index		2 months