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NCT05506098 Clinical Trial

Investigating STAT3 as a Driver of Pathology in Periodontitis

Periodontitis Clinical Trial

Official title:
Investigating STAT3 as a Driver of Pathology and Potential Therapeutic Target in Periodontitis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05506098
Other study ID # 11180389
Secondary ID FONDECYT 1118038
Status Completed
Phase
First received
Last updated
Start date March 20, 2019
Est. completion date October 20, 2022

Study information
Verified date January 2023
Source University of Chile
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Periodontitis is a prevalent inflammatory condition that destroys tooth-supporting structures. This condition is associated with pro-inflammatory mediators that utilize STAT3 as an activator of specific genes related to inflammation and tissue destruction. STAT3 has not been studied in the context of periodontitis in humans. We propose that STAT3 is associated with periodontitis. This knowledge might help to further our understanding of periodontitis pathology

Recruitment information / eligibility
Status Completed
Enrollment 28
Est. completion date October 20, 2022
Est. primary completion date October 20, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - 18-year-old, in good general health, and had no significant medical history. - no history of diabetes or other diseases different than periodontitis. Exclusion Criteria: - Pregnancy and lactation - Use of antibiotics, immunosuppressive agents, or probiotics within 3 months.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• no intervention
no intervention

Locations
Country Name City State
Chile Faculty of Dentistry, University of Chile Santiago

Sponsors (1)
Lead Sponsor Collaborator
University of Chile

Country where clinical trial is conducted

Chile, 

Outcome
Type Measure Description Time frame Safety issue
Primary STAT3 detection in gingival tissues Detection of STAT3 in gingival tissues 1 day
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