I-Smads in Periodontitis

Status Completed

Clinical Trial Summary

Recently, it has been stated that Smads play an active role in all conditions where transforming growth factor-beta (TGF-β) is involved, including periodontal inflammation. This study aimed to examine the levels of TGF-β and inhibitor Smads in saliva and gingival crevicular fluid (GCF) in patients with Stage 3 Grade B periodontitis before and after non-surgical periodontal treatment. Twenty (20) stage 3 grade B periodontitis and 20 periodontally healthy individuals were included in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and saliva samples were obtained at baseline and one month after treatment. TGF-β, Smad6, and Smad7 were determined by ELISA.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04846166
Study type	Observational [Patient Registry]
Source	Bulent Ecevit University
Contact
Status	Completed
Phase
Start date	August 1, 2019
Completion date	March 1, 2020

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04712630` - Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft	N/A
Completed	`NCT06127069` - Treatment of Residual Pockets in Periodontal Patients Using an Oscillating Chitosan Device	N/A
Completed	`NCT04964167` - Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis	Phase 4
Completed	`NCT05906797` - Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Periodontitis.	N/A
Recruiting	`NCT03997552` - NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration	N/A
Not yet recruiting	`NCT05530252` - Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis	Phase 4
Completed	`NCT04881357` - Antiplaque/Antigingivitis Effect of Lacer Oros Integral	N/A
Recruiting	`NCT03790605` - A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis	Phase 3
Enrolling by invitation	`NCT04971174` - Outcomes of Periodontal Regenerative Treatment
Not yet recruiting	`NCT05568290` - Interleukin-38 Levels in Individuals With Periodontitis
Completed	`NCT04383561` - Relationship Between LRG and Periodontal Disease	N/A
Recruiting	`NCT03997578` - Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects	N/A
Completed	`NCT03901066` - Smoking Dependence and Periodontitis
Enrolling by invitation	`NCT04956211` - Periodontal Treatment and Ischemic Stroke	N/A
Recruiting	`NCT05971706` - Ozone Application in Periodontal Treatment	N/A
Recruiting	`NCT06099574` - A Study on the Oral Health Status of Pregnant Women With Gestational Diabetes and Its Correlation With Oral Flora
Completed	`NCT04402996` - Meteorin-like Levels in Individuals With Periodontitis
Active, not recruiting	`NCT05311657` - Oral Health and Severe COPD
Not yet recruiting	`NCT05995431` - Impact of Bruxism in the Outcome of Subgingival Instrumentation for the Management of Stage 2 and Stage 3 Periodontitis.	N/A
Not yet recruiting	`NCT05643287` - The Effect of Time on the Outcome of Periodontal Treatment.	N/A