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Evaluation of Free Aminoacids in Saliva as A Diagnostic Biomarker of Periodontal Disease

Periodontitis Clinical Trial

Official title:
Evaluation of Free Aminoacids in Saliva as A Diagnostic Biomarker of Periodontal Disease

Clinical Trial Summary

Amino acids (AAs) are organic molecules that are associated with inflammation and innate immunity diseases with critical roles in the cell repair and protection process. Our aim was to identify the free amino acids in saliva of a group of periodontitis patients and healthy individuals and additionally to assess their levels in different periodontal disease types and compare it to the healthy individuals.

Clinical Trial Description

The study consisted of three groups: healthy individuals (control(C); n=20), Stage III Grade B generalized periodontitis (GP-B; n=20), and Stage III Grade C generalized periodontitis (GP-C; n=20). Clinical periodontal parameters (plaque index (PI), gingival index (GI), probing depth (PPD), gingival recession (GR), clinical attachment level (CAL) and bleeding on probing (BOP)) were measured. The amino acid analysis in saliva was accomplished by liquid chromatography-mass spectrometry (LC MS/MS) as mean concentration. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04642716
Study type Interventional
Source Istanbul Medipol University Hospital
Contact
Status Completed
Phase N/A
Start date April 20, 2015
Completion date August 3, 2017
View Details
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