Resolvin D1 Levels in Patients With Periodontitis

Periodontitis Clinical Trial

Official title:

The Role of Resolvin D1 in Maintaining Oral Health

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04496570
• Other study ID #: Ordu University Dental Faculty
• Status: Completed
• Phase: N/A
• Start date: July 31, 2019
• Est. completion date: February 29, 2020

Study information

• Verified date: August 2020
• Source: T.C. ORDU ÜNIVERSITESI
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels.

A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 26
• Est. completion date: February 29, 2020
• Est. primary completion date: February 29, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years to 60 Years

Eligibility

Inclusion Criteria:

• Stage 3, Grade B and generalized periodontitis patients

Exclusion Criteria:

• excessive forces;

• presence of systemic diseases

• administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months

• having received non-surgical periodontal treatment within the past 6 months

• allergy or sensitivity to any drug,

• pregnancy, lactation

• current and former use of tobacco.

Related Conditions & MeSH terms

• Periodontitis

Intervention

Procedure:
• periodontal therapy
Non surgical periodontal therapy was performed to patients with peridontitis

Locations

Country	Name	City	State
Turkey	Ordu University	Ordu

Sponsors (1)

Lead Sponsor	Collaborator
T.C. ORDU ÜNIVERSITESI

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Biochemical parameter (resolvin D1)	The changes in levels of resolvin D1 after periodontal treatment determined by ELISA.	Baseline and 1 month after NSPT
Secondary	Probing pocket depth	The changes in probing pocket depth after periodontal treatment were evaluated	Baseline and 1 month after NSPT
Secondary	Clinical attachment level (CAL)	The changes in CAL after periodontal treatment were evaluated	Baseline and 1 month after NSPT
Secondary	Plaque index (PI)	The changes in PI after periodontal treatment were evaluated	Baseline and 1 month after NSPT
Secondary	Gingival index (GI)	The changes in GI after periodontal treatment were evaluated	Baseline and 1 month after NSPT