Periodontitis Clinical Trial
Official title:
Clinical and Radiographic Changes Following Minimally-invasive Non-surgical Therapy in Teeth With Unfavourable Prognosis: A Pilot Prospective Cohort Study
This is a pilot prospective cohort study to assess the efficacy of minimally-invasive non-surgical periodontal therapy (MINST) for the treatment of teeth with unfavourable periodontal prognosis. 20 patients who have teeth with unfavourable periodontal prognosis (due to bone loss to the apex or furcation involvement grade II C) will receive minimally-invasive non-surgical treatment (MINST) and will be reassessed up to 12 months after treatment.
Twenty patients with advanced periodontitis who have teeth with unfavourable periodontal
prognosis (due to bone loss to the apex or furcation involvement grade II C) will be entered
in this study, conducted at Guy's Hospital in London, UK. The study has a prospective cohort
design, so following baseline assessment, all patients will receive minimally-invasive
non-surgical treatment (MINST). A total of 10 visits are planned over a 12-13 months period
including initial treatment (MINST) and follow-up appointments.
The primary outcomes are radiographic defect depth (for teeth with bone loss to the apex,
n=10) and furcation involvement (for teeth with furcation involvement degree II C, n=10).
Paired t-test will be used to detect significant changes between baseline and 12 months for
the primary outcomes using the patient as unit of analysis. Additional outcomes will be
probing pocket depths (PPD), clinical attachment level (CAL), levels of inflammatory markers
and growth factors in gingival crevicular fluid (GCF) and saliva and bacterial detection in
periodontal pockets
;
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