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Clinical Trial Summary

The aim of this study is to determine the efficacy of application of Lactobacillus Reuteri probiotics therapy on clinical improvement and on microbial shift in Chinese periodontitis patients.


Clinical Trial Description

Periodontitis is a chronic inflammatory disease with a prevalence of 80% in Chinese adults, which is the main cause of tooth loss in adults. Periodontitis has also been demonstrated to be a risk factor for cardiovascular diseases, diabetes, and many other systemic diseases due to the host immune response elicited by periodontal pathogenic bacteria. In the last decade, probiotics therapy using Lactobacillus Reuteri has been applied for periodontitis patients in European countries. But no evidence has been provided for its effectiveness in a Chinese population. The aim of this study is to determine the efficacy of application of Lactobacillus Reuteri probiotics therapy on clinical improvement and on microbial shift in Chinese periodontitis patients. The influence of probiotics therapy on the host inflammatory cytokines levels in periodontitis patients with systemic diseases is also evaluated. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04129684
Study type Interventional
Source Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact Yanmin Wu, Doctor
Phone +86 0571-87783607
Email wym731128@126.com
Status Recruiting
Phase N/A
Start date December 1, 2019
Completion date November 30, 2021

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