Periodontitis Clinical Trial
Official title:
Curcumin-Simvastatin Release Profile in the Gingival Crevicular Fluid Following EDTA Root Surface Etching in the Surgical Treatment of Intrabony Periodontal Defects - A Biochemical and Clinical Study
Verified date | August 2019 |
Source | Ain Shams University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Among the root conditioning materials is the Ethylenediaminetetraacetic acid (EDTA). EDTA exposes the collagen fibers on dentin surfaces and also enhances early cell colonization. Statins have an anti-inflammatory effect, inhibit the bone resorption and stimulate the bone formation. Curcumin is effective in preventing periodontal disease destruction by targeting both bacteria and host inflammatory cells. Curcumin has anti- inflammatory, antioxidant, anticarcinogenic, antiviral, and antimicrobial functions. This study will be carried out to examine the effect of simvastatin-curcumin paste following EDTA root surface etching when used in conjunction with open flap debridement treating deep periodontal pockets (suggesting that it may have positive effect)
Status | Completed |
Enrollment | 30 |
Est. completion date | October 3, 2018 |
Est. primary completion date | May 5, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 25 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Patient suffering at least a single posterior 2-3 wall periodontal Pocket of depth = 5 mm, attachment loss =3 mm, intrabony component =3 mm, plaque index =1 (Sillness and Loe, 1964) and sulcus bleeding index =1 (Mühlemann & Son, 1971). All these criteria were determined after phase I conventional periodontal therapy. - Systemically healthy as evidenced by burket's oral medicine health history question questionnaire (Glick et al., 2008). - Patients available during follow-up periods Exclusion Criteria: - Smoking - Patient unwilling to comply with periodontal hygienic instructions - Patients under any long-term chronic medication - Vulnerable individuals |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Ain Shams University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | clinical score | Probing depth (PD): evaluate the average reduction in probing depth measured in millimeters. Reduction in probing depth indicates that EDTA, simvastatin, and curcumin have positive effects in treatment. | change from base line to 6 months |
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