Periodontitis Clinical Trial
Official title:
Comparison of Effectiveness of Low Dose Aspirin Vs Omega 3 Fatty Acids as Adjuvants to Non-surgical Periodontal Therapy in Type II Diabetic Patients With Chronic Periodontitis
The main aim and objective of this study is to compare the effectiveness of low dose aspirin vs omega 3 fatty acids as adjuvants to non-surgical periodontal therapy and also to evaluate the levels of pentraxin 3 and glycosylated haemoglobin in diabetic patients with chronic periodontitis
There is an established bi-directional relationship between diabetes mellitus and
periodontitis. Periodontitis causes systemic inflammation by the entry of oral pathogens and
their virulence factors that adversely affect diabetic control in terms of elevated HbA1c
levels.
Host modulatory therapy (HMT) is a strategy prescribed as an adjunct to conventional
periodontal treatment by downregulating inflammation and promoting protective or regenerative
responses. Different drugs have been evaluated as HMT including NSAIDS, Doxycycline,
Bisphosphonates.
Aspirin has the unique position as HMT drug. It inhibits prostanoid production and induces
15- epi- lipoxins which are bioactive than native lipoxins.
Omega 3 fatty acids including Docosahexaenoic acid and Eicosapentaenoic acid due to their
anti-inflammatory, antithrombotic, hypolipidemia and vasodilator effect, reduce the
inflammatory mediators to levels of healthy tissues.
Pentraxins(PTX3) are classic acute phase proteins. They are a superfamily of evolutionarily
conserved proteins considered to be the markers of acute phase inflammation. PTX3 is also
known as TNF stimulated gene. It is produced abundantly in periodontal tissue by neutrophils,
fibroblasts, monocytes and epithelial cells. The plasma levels of PTX3 is raised in
inflammatory conditions. Hence it is taken as a biomarker.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04712630 -
Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft
|
N/A | |
| Completed |
NCT06127069 -
Treatment of Residual Pockets in Periodontal Patients Using an Oscillating Chitosan Device
|
N/A | |
| Completed |
NCT04964167 -
Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis
|
Phase 4 | |
| Completed |
NCT05906797 -
Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Periodontitis.
|
N/A | |
| Recruiting |
NCT03997552 -
NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration
|
N/A | |
| Completed |
NCT05530252 -
Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
|
Phase 4 | |
| Completed |
NCT04881357 -
Antiplaque/Antigingivitis Effect of Lacer Oros Integral
|
N/A | |
| Recruiting |
NCT03790605 -
A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis
|
Phase 3 | |
| Enrolling by invitation |
NCT04971174 -
Outcomes of Periodontal Regenerative Treatment
|
||
| Not yet recruiting |
NCT05568290 -
Interleukin-38 Levels in Individuals With Periodontitis
|
||
| Completed |
NCT04383561 -
Relationship Between LRG and Periodontal Disease
|
N/A | |
| Recruiting |
NCT03997578 -
Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects
|
N/A | |
| Completed |
NCT03901066 -
Smoking Dependence and Periodontitis
|
||
| Enrolling by invitation |
NCT04956211 -
Periodontal Treatment and Ischemic Stroke
|
N/A | |
| Recruiting |
NCT05971706 -
Ozone Application in Periodontal Treatment
|
N/A | |
| Recruiting |
NCT06099574 -
A Study on the Oral Health Status of Pregnant Women With Gestational Diabetes and Its Correlation With Oral Flora
|
||
| Completed |
NCT04402996 -
Meteorin-like Levels in Individuals With Periodontitis
|
||
| Active, not recruiting |
NCT05311657 -
Oral Health and Severe COPD
|
||
| Not yet recruiting |
NCT06453278 -
(DDS) in India: a Screening Tool to Identify Prediabetes and Undiagnosed Type 2 Diabetes in Dental Settings
|
||
| Not yet recruiting |
NCT05643287 -
The Effect of Time on the Outcome of Periodontal Treatment.
|
N/A |