Periodontitis Clinical Trial
Official title:
Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. A Randomized Clinical Trial
The accumulation and maturation of oral biofilm in the gingival margin is widely recognised
to be the primary aetiological factor in the development of chronic gingivitis. Based on
this association, the current treatment of gingivitis is focused on biofilm disruption,
which will normally include mechanical processes, both professionally and at home. However,
for patients, it is not easy to achieve a proper level of plaque control. The efficient
plaque control techniques are very time consuming and require a special motivation and
skills for their optimum use. It was at this point where mouthwashes become important, due
to the fact that they include diverse types of antimicrobial agents to complement the
results of mechanical oral hygiene measures.
The essential oils have been presented as a realiable alternative to the "gold Standard"
(Chlorhexidine). However, it use has been limited clinically due to their alcohol contain.
Some years ago, a new alternative without alcohol has been launched to the market. This
formulation has not been already deeply tested specific antiplaque studies in which the
structure of the biofilm remained intact.
The aim of this study was to evaluate the in situ antiplaque effect of 2 antimicrobial
agents (based on an essential oils formulation with and without alcohol) in the short term
with a posterior analysis on "non-destructured" biofilm with Confocal Laser Scanning
Microscope combined with fluorescence staining.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04712630 -
Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft
|
N/A | |
| Completed |
NCT06127069 -
Treatment of Residual Pockets in Periodontal Patients Using an Oscillating Chitosan Device
|
N/A | |
| Completed |
NCT04964167 -
Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis
|
Phase 4 | |
| Completed |
NCT05906797 -
Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Periodontitis.
|
N/A | |
| Recruiting |
NCT03997552 -
NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration
|
N/A | |
| Completed |
NCT05530252 -
Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
|
Phase 4 | |
| Completed |
NCT04881357 -
Antiplaque/Antigingivitis Effect of Lacer Oros Integral
|
N/A | |
| Recruiting |
NCT03790605 -
A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis
|
Phase 3 | |
| Enrolling by invitation |
NCT04971174 -
Outcomes of Periodontal Regenerative Treatment
|
||
| Not yet recruiting |
NCT05568290 -
Interleukin-38 Levels in Individuals With Periodontitis
|
||
| Completed |
NCT04383561 -
Relationship Between LRG and Periodontal Disease
|
N/A | |
| Recruiting |
NCT03997578 -
Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects
|
N/A | |
| Completed |
NCT03901066 -
Smoking Dependence and Periodontitis
|
||
| Enrolling by invitation |
NCT04956211 -
Periodontal Treatment and Ischemic Stroke
|
N/A | |
| Recruiting |
NCT05971706 -
Ozone Application in Periodontal Treatment
|
N/A | |
| Recruiting |
NCT06099574 -
A Study on the Oral Health Status of Pregnant Women With Gestational Diabetes and Its Correlation With Oral Flora
|
||
| Completed |
NCT04402996 -
Meteorin-like Levels in Individuals With Periodontitis
|
||
| Active, not recruiting |
NCT05311657 -
Oral Health and Severe COPD
|
||
| Not yet recruiting |
NCT05643287 -
The Effect of Time on the Outcome of Periodontal Treatment.
|
N/A | |
| Not yet recruiting |
NCT05995431 -
Impact of Bruxism in the Outcome of Subgingival Instrumentation for the Management of Stage 2 and Stage 3 Periodontitis.
|
N/A |