Periodontitis Clinical Trial
Official title:
The Effect of Periodontal Therapy on Epigenetic Changes: A Pilot Study
Objective: The aim of this pilot study is to evaluate the alterations of epigenetic patterns
in periodontally diseased individuals, before and after periodontal treatment, also in
comparison to periodontally healthy patients.
Materials & methods: Twenty patients were voluntarily enrolled in two groups: 10
participants with healthy periodontium, and 10 participants with chronic periodontitis.
Clinical parameters were recorded and gingival biopsies were collected within the following
timelines: At baseline (for both groups), after 15 days (for the diseased group only) and
after two months (for the diseased group only).
Study Design Baseline: Before harvesting gingival biopsies, bleeding on probing (BOP),
periodontal pocket depth (PPD) and clinical attachment level (CAL) were registered at the
biopsy site, for all study participants. Following the registration of the clinical
parameters, gingival biopsies were obtained from the periodontally-healthy individuals
during crown lengthening surgery or surgical removal of wisdom teeth. In the
periodontally-diseased group, biopsies were harvested from two sites: healthy site and
periodontally-involved site. After harvesting of biopsies, patients with periodontal disease
underwent scaling and root planing.
Two weeks after periodontal treatment: Clinical parameters were registered and gingival
biopsies were harvested (from two sites) for the periodontally-diseased group only, to
evaluate if the epigenetic patterns (DNA methylation) were altered by conventional
periodontal therapy, in comparison to the patterns observed at baseline for both diseased
and healthy groups.
Two months after initial periodontal treatment: Clinical parameters were registered and
gingival biopsies were harvested (from two sites) for the periodontally-diseased group only,
to evaluate if the epigenetic patterns were still altered by conventional periodontal
therapy, in comparison to the patterns observed at baseline for both diseased and healthy
groups, and at 15 days for the diseased group.
;
Time Perspective: Prospective
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