Periodontitis Clinical Trial
Official title:
Comparison of Cytokines Production and Cellular Recruitment in Gingival Crevicular Fluid (GCF) and Granulation Tissue From Periodontitis, Peri-implantitis and Healthy Patients Leading to Activation of Osteoclasts and Bone Resorption
Recent data found that peri-implantitis may differ from periodontitis at the histological
level in terms of extent and composition of the cellular components. From human biopsies, it
has been shown a deeper apical extension of the inflammatory cell infiltrate and a larger
proportion of granulocytes and macrophages in peri-implantitis lesions compared to
periodontitis lesions. Following experimental peri-implantitis, it has been observed a
continuing bone loss around dental implants after ligature removal; whereas, such a
progression was not observed around teeth after cessation of the experimental periodontitis.
The factors influencing the recruitment and the activation of osteoclasts in both diseases
have not been compared yet.
Hypothesis : The more rapid and more severe alveolar bone destruction occurring in
peri-implantitis compared to periodontitis is due at least in part to differences in the
inflammatory process in these diseases.
Aim: to study the cytokine profile produced by gingival explants from periodontitis or
peri-implantitis sites and to test the consequences on alteration of bone remodelling
activity using in vitro approach.
Materials and methods The investigators will establish a collection of human gingival
samples from patients undergoing surgical treatment of periodontitis or peri-implantitis.
The investigators will test pro-inflammatory cytokines and chemokines release and
consequences on osteoclast differentiation and activity.
n/a
Observational Model: Case Control, Time Perspective: Cross-Sectional
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