Single Session Of Antimicrobial Photodynamic Therapy Using Indocyanine

Status Completed

Clinical Trial Summary

In recent years, there has been a growing interest in the use of dental lasers for treatment of periodontal diseases. Commercially available photodynamic therapy for periodontal diseases utilizes methylene blue as a photosensitizer. In this study, the effects of a novel photosensitizer dye, indocyanine green (ICG), as an adjunct to nonsurgical treatment of chronic periodontitis will be evaluated.

Clinical Trial Description

Background and objective: Periodontal disease is caused by periodontal pathogens that colonize the dental plaque and the subsequent host-microbial interactions. The recent years have witnessed a rapid increase in the usage of Light Amplification by Stimulated Emission of Radiation (Laser) in dentistry for the treatment of periodontal diseases. The additive therapeutic effects when a photoactivated dye such as methylene blue is used in conjunction with Laser is well documented. Indocyanine green (ICG), a tri-carbocyanine that belongs to family of cyanine dyes is widely used in the fields of Ophthalmology and Cardiac imaging. Recent in vitro studies have reported its efficacy in killing potent periodontal pathogens like A. actinomycetemcomitans and P. gingivalis when combined with 810 nm diode laser. The present study aims at evaluating the effects of ICG as an adjunct to non-surgical treatment of chronic periodontitis in biofilm environment of human periodontal pockets in terms of immediate reduction in percentage of viable bacteria and at the same to quantitatively assess host tissue injury. Methods: The study included 30 patients diagnosed with chronic periodontitis. Three sites from three different quadrants were selected and assigned to three groups namely, SRP group - scaling and root planing, LASER group - scaling and root planing with application of 810 nm diode laser and ICG group - scaling and root planing with application of 810 nm diode laser and ICG at a concentration of 5 mg/mL. Primary parameters included estimation of decrease in percentage of viable bacteria at baseline, immediate post treatment and end of 1 week and Lactate dehydrogenase (LDH) levels at baseline and end of 1 week. Secondary parameters included site-specific measures of plaque, gingivitis, pocket depth (PD) and clinical attachment loss (CAL) at specific time intervals. ;

Study Design

Related Conditions & MeSH terms

Periodontitis

Clinical Trial Details

NCT number	NCT02043340
Study type	Interventional
Source	SVS Institute of Dental Sciences
Contact
Status	Completed
Phase	Phase 2
Start date	October 2012
Completion date	December 2013

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04712630` - Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft	N/A
Completed	`NCT06127069` - Treatment of Residual Pockets in Periodontal Patients Using an Oscillating Chitosan Device	N/A
Completed	`NCT04964167` - Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis	Phase 4
Completed	`NCT05906797` - Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Periodontitis.	N/A
Recruiting	`NCT03997552` - NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration	N/A
Completed	`NCT05530252` - Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis	Phase 4
Completed	`NCT04881357` - Antiplaque/Antigingivitis Effect of Lacer Oros Integral	N/A
Recruiting	`NCT03790605` - A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis	Phase 3
Enrolling by invitation	`NCT04971174` - Outcomes of Periodontal Regenerative Treatment
Not yet recruiting	`NCT05568290` - Interleukin-38 Levels in Individuals With Periodontitis
Completed	`NCT04383561` - Relationship Between LRG and Periodontal Disease	N/A
Recruiting	`NCT03997578` - Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects	N/A
Completed	`NCT03901066` - Smoking Dependence and Periodontitis
Enrolling by invitation	`NCT04956211` - Periodontal Treatment and Ischemic Stroke	N/A
Recruiting	`NCT05971706` - Ozone Application in Periodontal Treatment	N/A
Recruiting	`NCT06099574` - A Study on the Oral Health Status of Pregnant Women With Gestational Diabetes and Its Correlation With Oral Flora
Completed	`NCT04402996` - Meteorin-like Levels in Individuals With Periodontitis
Active, not recruiting	`NCT05311657` - Oral Health and Severe COPD
Not yet recruiting	`NCT06453278` - (DDS) in India: a Screening Tool to Identify Prediabetes and Undiagnosed Type 2 Diabetes in Dental Settings
Not yet recruiting	`NCT05643287` - The Effect of Time on the Outcome of Periodontal Treatment.	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Single Session Of Antimicrobial Photodynamic Therapy Using Indocyanine Green

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms