Periodontitis Clinical Trial
Official title:
Assessment of Use of Plasma or Serum IgG Test to Screen for Periodontitis
This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.
Background: Periodontitis is a prevalent silent infectious disease worldwide, and affects
lifestyle-related diseases such as diabetes. Therefore, efficient screening of patients is
essential for general health. This study was performed to evaluate prospectively the
diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.
Methods: Oral examination was performed and blood IgG antibody titers against periodontal
pathogens were measured by ELISA, in 1387 subjects. The cut-off value of IgG titer was
determined in receiver operating characteristic curve analysis, and changes in periodontal
clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships
between IgG titers and severity of periodontitis were analyzed.
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