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NCT03345745 Clinical Trial

Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients

Periodontal Inflammation Clinical Trial

Official title:
The Short-Term Effects of Non-Surgical Periodontal Therapy on The Saliva Levels of S100A12, High-Sensitivity C-Reactive Protein and Fetuin-A in Patients With Gingivitis and Chronic Periodontitis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03345745
Other study ID # OrduUniversityDentistry
Secondary ID
Status Completed
Phase N/A
First received November 13, 2017
Last updated November 16, 2017
Start date February 1, 2017
Est. completion date September 1, 2017

Study information
Verified date November 2017
Source T.C. ORDU ÜNIVERSITESI
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before and after non-surgical periodontal treatments in the patients with periodontal diseases.

A total of 54 subjects were divided in to three groups; periodontally healthy (n: 18), gingivitis (n: 18), chronic periodontitis (n: 18). Clinical periodontal parameters, salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments. Salivary Hs-CRP, Fetuin-A and S100A12 levels were assayed by ELISA.

Recruitment information / eligibility
Status Completed
Enrollment 54
Est. completion date September 1, 2017
Est. primary completion date June 1, 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

never-smokers no history of systemic disease no patients had been under periodontal therapy and medicine for at least 6 months before the study no pregnancy or lactation no alcohol or antioxidant vitamin consumption.

Exclusion Criteria:

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• salivary samples
Salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments

Locations
Country Name City State
Turkey Ordu University Ordu

Sponsors (1)
Lead Sponsor Collaborator
T.C. ORDU ÜNIVERSITESI

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Salivary acute phase proteins Fetuin-A Baseline - a month after the periodontal treatments
Primary Salivary acute phase proteins S100A12 Baseline - a month after the periodontal treatments
Primary Salivary acute phase proteins C-Reactive Protein Baseline
Secondary Evaluating periodontal health plaque index Baseline - a month after the periodontal treatments
Secondary Evaluating periodontal health gingival index Baseline - a month after the periodontal treatments
Secondary Evaluating periodontal health probing depth Baseline
Secondary Evaluating periodontal health clinical attachment level Baseline - a month after the periodontal treatments
Secondary Evaluating periodontal health gingival bleeding on probing Baseline - a month after the periodontal treatments
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