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Comparison of Salivary Parameters in Patients Receiving CoQ10 and Vitamin E Supplementation

Periodontal Diseases Clinical Trial

Official title:
Comparison of Salivary Markers in Patients With Initial Chronic Periodontitis After Non-surgical Periodontal Treatment With CoQ10 Supplementation With Vitamin E

Clinical Trial Summary

Comparison of salivary markers in patients with Initial chronic periodontitis after non-surgical periodontal treatment with CoQ10 supplementation with vitamin E

Clinical Trial Description

This research was structured as a double-blind, randomized clinical trial aimed at assessing the effectiveness of CoQ10 and Vitamin E supplements on periodontal health in patients with chronic periodontitis. A total of 75 patients from the Department of Periodontics at Broujerd Dental School of the Islamic Azad University of Medical Sciences were chosen for the study. Before the commencement of the trial, various clinical periodontal parameters such as plaque index, bleeding on probing, gingival index, probing depth, and clinical attachment level were measured in six different areas of the tooth surface. Subsequently, scaling and root planning were carried out, and oral hygiene practices were enhanced for all participants. The participants were then randomly divided into three groups: Group A received 30 mg of CoQ10, Group B was provided with 400 mg of Vitamin E supplements daily, and Group C did not receive any medication. After two months, the clinical periodontal parameters were reevaluated. Furthermore, to compare the total antioxidant capacity in saliva before and after the administration of these supplements, as well as in patients who did not receive any medication, 2 ml of non-stimulated saliva was collected from each participant at the beginning and end of the study for analysis using UV-spectrophotometric methods. The selection criteria for eligible participants in this study were also clearly defined. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06373848
Study type Interventional
Source Islamic Azad University, Tehran
Contact
Status Enrolling by invitation
Phase N/A
Start date April 20, 2024
Completion date September 15, 2024
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