Application of L-PRF in Periodontal Surgery

Status Recruiting

Clinical Trial Summary

The study will compare the clinical outcomes of the two procedures, open flap debridement (OFD) compared to open flap debridement with leukocyte and platelet-rich fibrin (L-PFR) as well as differences in patient postoperative pain perception.

Clinical Trial Description

Randomization to one of two standard of care procedures: 1. Test group: After gingival flap reflection and debridement of bone and root surfaces L-PRF will be applied to the alveolar bone, tooth roots, and gingival flap prior to suturing. 2. Control group (Standard of care): Gingival flap reflection and debridement of bone and root surfaces, followed by suturing of the gingival flaps. The study is a split-mouth design, randomized, prospective clinical trial. The protocol will randomize gingival quadrants in subjects to one of two standard of care procedures OFD or OFD + L-PRF. Patients needing periodontal surgery to correct periodontal disease will be enrolled. There will be two subject groups in this study. Each subject will be randomized to one of the treatments for the first quadrant and the contralateral quadrant will receive the other treatment. No risk is expected from being assigned to either group as both procedures are standard of care, with possible benefit of enhanced wound healing and bone regeneration in the test group. Allocation of subjects into test group or control group will be based on numbers drawn from a stack of sealed envelopes. ;

Study Design

Related Conditions & MeSH terms

Periodontal Diseases

Clinical Trial Details

NCT number	NCT06296498
Study type	Interventional
Source	The University of Texas Health Science Center at San Antonio
Contact	Charles Powell, DDS, MS
Phone	210-567-3593
Email	powellc2@uthscsa.edu
Status	Recruiting
Phase	N/A
Start date	August 19, 2023
Completion date	March 2026

View Details

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