Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT06201975 |
| Other study ID # |
23-062 |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
January 1, 2024 |
| Est. completion date |
February 20, 2024 |
Study information
| Verified date |
January 2024 |
| Source |
British University In Egypt |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
Periodontal diseases are disease processes involving the periodontium, a term used to
describe the supportive apparatus surrounding the tooth, which includes the gingival tissue,
alveolar bone, cementum, and periodontal ligament. Thyme honey, as a conventional therapy,
might be a novel antioxidant to abate many of the diseases directly or indirectly associated
with oxidative stress. To the best of the researchers' knowledge, there are no published
studies on the management of periodontitis in using locally delivered Thyme honey.
Description:
In 2017, the American Academy of Periodontology, in collaboration with the European
Federation of Periodontology, devised a new classification of periodontal and peri-implant
diseases. In this new classification, periodontitis can be subdivided into three categories,
Necrotizing periodontal diseases, Periodontitis, Periodontitis as a manifestation of systemic
diseases.
Non-surgical treatment is valuable in mild to moderate periodontitis whereas surgical
treatment is useful in progressive cases. Confined drug delivery systems-mouth rinses,
irrigating solutions and sustained release devices are used for distribution of antimicrobial
agents.
It has been observed that artificial antimicrobial agents and antibiotics are identified to
cause antimicrobial resistance. It has also been observed that appearance of formerly rare
infections is on the rise perhaps due to the incorrect or prevalent overuse of
antimicrobials. Natural phytochemicals have demonstrated to be worthy substitutes to
synthetic agents.
It is interesting fact to note that two of the most populated countries in the world China
and India, have used herbal medicine for the managing of oral infections, comprising
periodontal disease as well for more than a duration of 2000 years.
It has been found that in adults with chronic periodontitis, scaling and root planning along
with use of an adjunctive antimicrobial mediator increases patient outcomes over a period of
time compared to scaling alone. Modern chemotherapeutic agents display significant efficacy
in improving periodontal health but owing to undesirable side effects such as tooth
discoloration, taste alteration, and price of these substances, the usage of herbal products
has increased lately and could be especially of high benefit to lower socioeconomic
populations around the world.
Herbal medicines and preparations comprise of plant constituents professed to have
therapeutic benefits. Herbal products are favored over conventional drugs owing to extensive
natural activity, advanced safety margin, and inferior costs. Additionally, the modern drugs
are known to cause several side effects. Continuous intake of modern drugs has sometimes
caused in antibiotic resistance thereby herbal medicines are being used gradually as dietary
add-ons to combat or avert common ailments affecting human body and oral cavity.
Honey as a natural product has clinched the attention of researchers as a complementary and
alternative medicine. Honey as a folk medicine is referred in the utmost ancient written
archives.
Demarcation of its uses in current professional medicine as a potential therapy is entirely
underutilized. However, there is an affinity for some researchers to fire out a coherent
proposition that usage of honey as a natural product supplement is well intentioned for
reflection as a therapy or adjuvant antioxidant therapy in current medicine. The composition
of honey varies from floral source to origin.
Thyme honey has been studied against various ailments in animal and human models. Published
research denotes it as a novel antioxidant agent. It exhibits a broad spectrum therapeutic
properties such as anti-inflammatory, antibacterial, antimutagenic, expedite wound healings,
antidiabetic, antiviral, antifungal, and antitumor effects.
Additionally, the anti-inflammatory properties of Greek thymus vulgaris extract was examined
in recent research which reported its ability to reduce the LPS-induced elevation in
cyclooxygenase (COX)-2, nuclear factor-kappa B (NF-кB), TNF-α, and produced a more potent
attenuating effect than dexamethasone for most of the studied inflammatory mediators.
Moreover, thymol was reported to possess an inhibitory effect on TNF-α, IL-6, IFN-γ, IL-1β
and IL-17, C-reactive protein and myeloperoxidase. Furthermore, unfractionated essential oil
from T. vulgaris was found to reduce neutrophil infiltration during inflammatory
response.Thyme honey, as a conventional therapy, might be a novel antioxidant to abate many
of the diseases directly or indirectly associated with oxidative stress. To the best of the
researchers' knowledge, there are no published studies on the management of periodontitis in
using locally delivered Thyme honey.
