Hydroxylated Polymethoxy Flavones Solid Dispersion in Treatment of

Status Not yet recruiting

Clinical Trial Summary

Periodontitis is a serious gum infection that damages the soft tissue and, without treatment, can destroy the bone that supports your teeth. Hydroxylated poly methoxy flavones are a combination of naturally occurring flavonoids extracted from the orange peel and exert anti-inflammatory, antibacterial, and antifungal activity however, this extract is poorly soluble and poorly absorbable. In this work, this extract was formulated as a solid dispersion formulation to enhance its biological activity and then incorporated into a gel base and used in the treatment of periodontitis after clinical debridement.

Clinical Trial Description

In the study, there are 3 groups; the first one first one received plain sodium carboxymethylcellulose. Group II received chlorhexidine gel. GroupIII received Hydroxylated poly methoxy flavones solid dispersion incorporated into sodium carboxymethylcellulose gel. In all groups, there is clinical debridement before injection of gels. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05546788
Study type	Interventional
Source	Assiut University
Contact
Status	Not yet recruiting
Phase	Phase 1
Start date	October 20, 2023
Completion date	November 20, 2023

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Hydroxylated Polymethoxy Flavones Solid Dispersion in Treatment of Periodontitis

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms