Application of Hyaluronic Acid in Diabetes

Periodontal Diseases Clinical Trial

Official title:

Evaluation of The Clinical & Radiographic Parameters in Controlled Type 2 Diabetic Patients Treated With Non-Surgical Periodontal Therapy With & Without Using Hyaluronic Acid Gel

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05543434
• Other study ID #: Reem
• Status: Recruiting
• Phase: N/A
• Start date: December 1, 2022
• Est. completion date: December 1, 2023

Study information

• Verified date: September 2022
• Source: Cairo University
• Contact: Reem M Alabbadi, BDS
• Phone: 00201551563633
• Email: reem.alabbadi[@]dentistry.cu.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

sub gingival application of hyaluronic acid create great clinical improvement of periodontal pocket treatment.

Description:

To clinically and radiographically evaluate the adjunctive effect of the local application of a 0.8% hyaluronan gel in addition to scaling and root planing in treatment of controlled diabetic patients with stage II periodontitis.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 26
• Est. completion date: December 1, 2023
• Est. primary completion date: March 1, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Age = 18 years.

• Patient with controlled diabetic type 2 (HgA1C <7) (Mori et al., 2021).

• Periodontitis stage II.

• Periodontitis grade B.

• Pocket depth > 4 mm.

• Smoking = 10 cigarettes/day.

• Cooperative patients able and accept to come for follow up appointments

Exclusion Criteria:

• • The use of antibiotics or anti-inflammatory drugs 1 month prior to the procedure and till the end of 6 months of follow-up.

• Having surgical therapy or undergoing orthodontic treatment.

• Ongoing drug therapy that might have an impact on the clinical signs and symptoms of periodontitis.

• Pregnant and lactation females.

• Smoking ? 10 cigarettes/day.

• Patients with poor oral hygiene.

• Any known allergies

Related Conditions & MeSH terms

• Periodontal Diseases

Intervention

Drug:
• Hyaluronic acid
anti-inflammatory, anti-edematous, osseoinductive.

Locations

Country	Name	City	State
Egypt	faculty of dentistry Cairo university	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Clinical attachment level gain	Clinical attachment gain by using UNC15 Periodontal probe/ numerical data	3 months
Secondary	Pocket depth reduction	Pocket depth reduction by using UNC15 Periodontal probe/ numerical data	3 moths
Secondary	Bleeding on probing	Bleeding on probing by using UNC15 Periodontal probe/ binary data	3 months
Secondary	Gingival Recession	Gingival Recession by using UNC15 Periodontal probe/ numerical data	3 months
Secondary	Radiographic Evaluation	by using periapical radiograph with standardized acrylic stent	3 months