Periostin and Non-Surgical Periodontal Treatment

Periodontal Diseases Clinical Trial

Official title:

The Effect of Non-Surgical Periodontal Treatment on Gingival Crevicular Fluid Periostin Levels in Patients With Gingivitis and Chronic Periodontitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04332965
• Other study ID #: 2017/43
• Status: Completed
• Phase: N/A
• Start date: January 2017
• Est. completion date: April 2018

Study information

• Verified date: April 2020
• Source: Kirikkale University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.

Description:

Periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. Additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. Periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina.

This study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: April 2018
• Est. primary completion date: January 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 60 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of chronic periodontitis

• Clinical diagnosis of gingivitis

• Clinical diagnosis of periodontal health

Exclusion Criteria:

• have any systemic disease

• to be alcohol consumer

• to receive any periodontal therapy in the past 6 months

• to take any drugs regularly

• to be pregnant and/or lactate

Related Conditions & MeSH terms

• Chronic Periodontitis
• Periodontal Diseases

Intervention

Procedure:
• Non-Surgical Periodontal Treatment
Scaling and root planing and polishing with specific curettes were performed to patients and oral hygiene education was provided to each patient.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Kirikkale University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in periostin	Total amount of Periostin (pg/30 sec) in gingival crevicular fluid	Baseline, 6th week and 3rd month
Secondary	Change in periodontal clinical parameter	Clinical attachment level (mm) (from cemento-enamel junction to the base of periodontal pocket)	Baseline, 6th week and 3rd month