Periodontal Diseases Clinical Trial
Official title:
Mechanism of Indocyanine Green-based Photodynamic Therapy for Treating Periodontitis
The aim of this study was to investigate the mechanism of indocyanine green photodynamic
therapy (PDT) in periodontal therapy. The investigators will recruit 80 participants
receiving conventional periodontal disease treatment, or can not fully accept the regular
periodontal treatment of adult periodontal disease, photodynamic therapy, and oral
periodontal disease of the teeth as the control group, before treatment , Gingival crevicular
fluid and dental plaque were collected at 6 weeks, and 6 months after the treatment. The
biochemical indexes and strains were analyzed and the data of the participants Term
periodontal index.
In this study, indocyanine photodynamic therapy can improve the discomfort of patients with
periodontal disease and the periodontal index, the treatment area of the bacteria and the
inflammatory response will be significantly decreased, and look forward to this study can
establish the indigo cyanine light dynamic teeth Week therapies to provide periodontal
patients with more comfortable and effective clinical therapy.
The investigators will recruit 80 adult participants (20 to 80 years old) with periodontal
disease who do not receive a regular periodontal course of treatment, or who are unable to
receive the regular periodontal treatment completely, using a split-mouth design, meaning
that participants are treated with photodynamic therapy of the area for the experimental
area, while the mouth corresponding to the location of the area without violations of
periodontal disease control area. Participants signed the consent form, the first full-mouth
calculus removal and oral hygiene education, and in the experimental area after a week to
start photodynamic therapy. The investigators will inject indocyanine in the experimental
area, and the wavelength of 810 nm, the energy density of 4.5-9 J / cm2 of the diode laser
irradiation; indocyanine and will be cleared after the completion of irradiation, the control
area will not For any treatment. After the first treatment, a second, identical treatment
will be performed at intervals of 7-10 days. If there is no improvement after 6 weeks, the
participant will be treated for the third time.
Participants underwent periodontal examinations in the experimental and control areas at the
beginning of the first photodynamic therapy (T0), after six weeks (T1), and six months later
(T2), and record the periodontal pocket depth Gingival recession, plaque index and gingivitis
index were measured, and the gingival crevicular fluid was obtained by sterilizing the paper
needle. The gingival crevicular gingival crevicular gingival crevicular gingival crevicular
Fluid, and the use of a periodontal curette to obtain subgingival plaque. The gingival
crevicular fluid was quantified using the Periotron 8100 and the concentration of
proinflammatory cytokines such as IL-1, IL-10, MMP-8, etc. in the gingival crevicular fluid
was analyzed by ELISA kits; DNA was extracted and the periodontal pathogens such as P.
gingivalis and T. denticola were detected by Realtime PCR.
In addition, pain assessment was performed with a visual analogue scale at the time of
initiation of photodynamic therapy, weekly during the first 6 weeks after initiation of
photodynamic therapy, and at 6 months after initiation of treatment . Through these clinical,
physiological indicators, as well as the subject experience records, more effective and
objective assessment of photodynamic therapy and the establishment of adjuvant therapeutic
mechanism.
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