Periodontal Diseases Clinical Trial
Official title:
Screening of Epigenetic Biomarkers (miRNA) in the Gingival Sulcus
Epigenetics has produced a high impact in biomedical research and is providing new biomarkers
for the diagnosis and prognosis of diseases. In addition, epigenetics is also contributing to
analyze the molecular causes underlying diseases, even so periodontal diseases as it has been
recently reviewed. In this regard, changes in the methylation of genes codifying for
pro-inflammatory and anti-inflammatory cytokines has been previously reported. miRNAs are
very promising biomolecules to be used as biomarkers because miRNAs act as signaling
molecules and participate in many biological processes, such as cellular development,
differentiation, and apoptosis. The high stability of circulating miRNAs in the RNase-rich
environment of the bloodstream and also in different biospecimens used in clinical routine,
make these biomolecules an optimal source of candidate biomarkers. In fact, miRNAs have
demonstrated their value as dynamic biomarkers in a wide variety of human diseases.
Therefore, miRNAs can be used for the monitoring of periodontal disease.
The objective of this research is to analyze the levels of bone remodeling RANKL / OPG
biomolecular markers, and the epigenetic regulation of these proteins to identify promising
biomarkers of periodontal disease.
Material and Methods. Levels of RANKL and OPG will be measured in the gingival crevicular
fluid (GCF) to assess the state of bone. These samples will be sent to the lab for
quantification by ELISA method.
Furthermore, new epigenetic biomarkers based on the identification of high stable microRNAs
will be identified by qRT-PCR in GCF as feasible tools for diagnosis and monitoring of wide
range of disease, including periodontal disease.
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