Effects of Antimicrobial Photodynamic Therapy on Regeneration of Class II Furcation Lesions

Periodontal Diseases Clinical Trial

Official title:

Effects of Antimicrobial Photodynamic Therapy Associated to Biomaterials on Regeneration of Class II Furcation Lesions

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03264118
• Other study ID #: BauruSchoolDentistryfurcation
• Status: Completed
• Phase: N/A
• Start date: April 2, 2017
• Est. completion date: December 22, 2018

Study information

• Verified date: February 2023
• Source: University of Sao Paulo
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to evaluate the additional effect of antimicrobial photodynamic therapy regeneration treatment of mandibular furcation lesions when associated to bovine bone and porcine collagen membrane.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: December 22, 2018
• Est. primary completion date: December 22, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of class II furcation lesion in mandibular 1st and 2nd molars

• Mandibular 1st and 2nd molars without caries, erosion or abrasion

Exclusion Criteria:

• Smoking habit

• Pregnancy

• Use of antibiotics in the last six months

• Periodontal treatment in the last six months

• Endodontic lesion

• Systemic diseases that impair wound healing

Related Conditions & MeSH terms

• Alveolar Bone Loss
• Chronic Periodontitis
• Periodontal Bone Loss
• Periodontal Diseases
• Periodontitis
• Periodontitis, Chronic

Intervention

Procedure:
• Scaling and root planing
Furcation treatment by scaling and root planing

Drug:
• Toluidine Blue O
Antimicrobial photodynamic therapy with toluidine blue O (10mg/ml) and red laser.

Locations

Country	Name	City	State
Brazil	Bauru School of Dentistry	Bauru	Sao Paulo
Brazil	Bauru School of Dentistry	Bauru

Sponsors (2)

Lead Sponsor	Collaborator
University of Sao Paulo	Geistlich Pharma AG

Country where clinical trial is conducted

Brazil, 

References & Publications (2)

Avila-Ortiz G, De Buitrago JG, Reddy MS. Periodontal regeneration - furcation defects: a systematic review from the AAP Regeneration Workshop. J Periodontol. 2015 Feb;86(2 Suppl):S108-30. doi: 10.1902/jop.2015.130677. — View Citation

Luchesi VH, Pimentel SP, Kolbe MF, Ribeiro FV, Casarin RC, Nociti FH Jr, Sallum EA, Casati MZ. Photodynamic therapy in the treatment of class II furcation: a randomized controlled clinical trial. J Clin Periodontol. 2013 Aug;40(8):781-8. doi: 10.1111/jcpe.12121. Epub 2013 Jun 3. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Horizontal probing depth	Measured with a periodontal probe (mm). Ideal if 0.	one year
Primary	Tomographic Bone filling	Complete filling of furcation defect in tomographic images. Ideal is a radiopaque image similar to neighbor bone.	One year
Secondary	Probing depth	Distance from gingival margin to bottom of sulcus. Measured with a periodontal probe (mm). Ideal if < 2 mm.	one year
Secondary	Clinical Attachment Level	Distance from cemento-enamel junction to bottom of sulcus. Measured with a periodontal probe (mm). Ideal if < 2 mm.	one year
Secondary	Bleeding on probing	Visual confirmation of bleeding after probing. Ideal if not bleeding.	One year