Perinatal Mortality Clinical Trial
Official title:
Predictive Score for Neonatal Mortality for Women With Premature Rupture of Membranes Between 22 and 28 Weeks of Gestation
Pretern premature rupture of the membranes (PPROM) remains the leading cause of preterm
deliveries and neonatal mortality and morbidity. PPROM is defined as rupture of the fetal
membranes prior to 37 weeks' gestation. PPROM complicates 2-4% of all pregnancies and
accounts for approximately 30 % of preterm births.
The etiology of PPROM remains elusive. PPROM is one of the main causes of prematurity and
its complications, such as newborn respiratory distress syndrome, neonatal sepsis,
necrotizing enterocolitis, intraventricular hemorrhage, perventricular leucomalacia, varying
degrees of lung hypoplasia and bronchopulmonary dysplasia. All these factors contribute
greatly to an increase in neonatal morbidity and mortality Management of PPROM followed
actual guidelines. Conservative management to prolong a pregnancy is a classical approach to
treat PPROM before 34 weeks' gestation in association with antibiotic therapy and
corticosteroids.
Maternal and neonatal data were collected from maternal and newborns medical records.
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