Clinical Trials Logo
  1. Home
  2. Pericardial Effusion
  3. NCT02260206
  4. Details
NCT02260206 Clinical Trial

Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion

Pericardial Effusion Clinical Trial

Official title:
Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02260206
Other study ID # colchicine
Secondary ID
Status Completed
Phase Phase 4
First received
Last updated
Start date July 2014
Est. completion date October 2023

Study information
Verified date April 2024
Source Seoul St. Mary's Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The effects colchicine administration for acute pericardial effusion after radiofrequency catheter ablation (RFCA) of atrial fibrillation on the recurrences of arrhythmia.

Description:

RFCA was started as a rhythm control of atrial fibrillation about 10 years before and the superiority of RFCA to medical treatment has been continuously reporting, so RFCA is globally performed nowadays. Acute pericardial effusion could occur during RFCA as complication, that might be developed to cardiac tamponade needed immediate pericardiocentesis. The inflammation developed after pericardiocentesis might be associated with the recurrences of atrial fibrillation, it could be presumed by the frequent occurrence of atrial fibrillation after open-heart surgery. The inflammation can be suppressed by administration of colchicine and the effects of colchicine have been proven to decrease the development of atrial fibrillation.

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date October 2023
Est. primary completion date September 2019
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Patients needed to pericardiocentesis during RFCA for paroxysmal or persistent atrial fibrillation. Exclusion Criteria: - Hypersensitivity on Colchicine - The existence of intra-cardiac thrombus on trans-esophageal echocardiography - Pregnancy

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Colchicine
Impact of Colchicine therapy on arrhythmia Recurrence after Acute Pericardial Effusion following Catheter Ablation of Atrial Fibrillation

Locations
Country Name City State
Korea, Republic of Seoul St Mary's Hospital Seoul Seo Cho Gu

Sponsors (1)
Lead Sponsor Collaborator
Yong Seog Oh

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary recurrence of atrial arrhythimia Assessment of the recurrence of atrial arrhythimia 1 year after colchicines administration 1 year after colchicines administration
Secondary recurrence of atrial arrhythimia Assessment of the recurrence of atrial arrhythimia 3 year after colchicines administration 3 year after colchicines administration
See also
  Status Clinical Trial Phase
Completed NCT02045641 - Pleural and Pericardial Effusion Following Open Heart Surgery N/A
Completed NCT03327688 - Point-of-care Ultrasound in Finland N/A
Completed NCT02808897 - Active Clearance of Chest Tubes After Cardiac Surgery: A Prospective Randomized Controlled Study N/A
Not yet recruiting NCT06293924 - Pericardial Fluid Analysis in Recurrent Pericarditis
Active, not recruiting NCT01552187 - COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial) Phase 3
Completed NCT00247052 - Non Steroidal Anti Inflammatory Treatment for Post Operative Pericardial Effusion Phase 4
Completed NCT05061914 - Surgical Options for Management of Pericardial Effusion N/A
Completed NCT00684125 - Evaluation of Different Strategies of Pericardial Drainage After Aortic Valvular Surgery N/A
Recruiting NCT05146492 - Pericardial Effusion From Acute Myocardial Infarction: Contributing Factors and Prognosis at One Year (EPERICARDIM) N/A
Active, not recruiting NCT05077111 - A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia Phase 4
Recruiting NCT02673879 - IMPI 2 - A Trial of Intrapericardial Alteplase in Large Pericardial Effusion Phase 3
Recruiting NCT01665495 - Drainage or Pericardiocentesis (DROP) Alone for Recurrent Non-malignant Pericardial Effusions Requiring Intervention N/A
Recruiting NCT04464655 - A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease
Recruiting NCT06159985 - Effect of Left Posterior Pericardiotomy for the Prevention of POAF N/A
Completed NCT01266694 - Cochicine Treatment for Post- Operative Pericardial Effusion Phase 4
Recruiting NCT04279327 - Cell Block Immunohistochemistry in Effusion Cytology
Completed NCT03887286 - Focused Cardiac Ultrasound N/A