Periapical Periodontitis Clinical Trial
Official title:
Assessment of the Outcome of Endodontic Treatment Using Cone Beam Computed Tomography-A Prospective Study
The aim of the study is to assess the correlation between pre-obturation bacterial detection using fluorescence amplification and outcome of endodontic treatments. Thus, enabling a suitable detection threshold to predict the likelihood of treatment failure. This has the potential to be used a bench side tool in general dental practice to act as a surrogate endpoint for clinicians performing root canal treatment.
Pre-obturation root canal samples were taken using paper points from patients undergoing
primary root treatments. The samples were analyzed using a fluorescent spectrometer and a
molecular fluorescent vital dye (Calcein AM).
Pre-operative and 1-year post-operative periapical radiographs and Cone Beam Computed
Tomography (CBCT) scans were assessed by two calibrated expert examiners to evaluate the
outcome of the root canal treatments.
The use of a chairside bacterial stain can allow the clinician to predict the outcome of
treatment with confidence. Sampling the root canal space with endodontic paper points
followed by ex-situ fluorescent staining and analysis provides a patient-friendly, simple to
use and rapid way of predicting root canal treatment outcome.
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